Modulation of hyperthermic and relaxometric responses of magnetic iron oxide nanoparticles through ligand exchange provides design criteria for dual-functionality

• Published in: Journal of materials chemistry. C, Materials for optical and electronic devices Materials for optical and electronic devices, 2023-05, Vol.11 (19), p.6417-6428
• Main Authors: Aluri, Esther Rani, Shingte, Sameer D, McKiernan, Eoin P, Ferguson, Steven, Brougham, Dermot F
• Format: Article
• Language: English
• Subjects: Design criteria; Dilution; Heating; Iron oxides; Ligands; Magnetic resonance imaging; Nanoparticles; NMR; Nuclear magnetic resonance; Optimization; Parameter modification; Thermal decomposition
• ISSN: 2050-7526; 2050-7534
• DOI: 10.1039/d3tc00489a

Magnetic iron oxide nanoparticles (MNPs) are the subject of intense study as theranostic tools that combine magnetic resonance imaging (MRI)-trackability with AC-field responsive heating. In this study, we report MNPs synthesised using a modification of an established thermal decomposition method which, following extensive parameter optimisation, provides strong hyperthermic heating efficacy that is reproducible batch to batch. The suspensions have an exceptional specific absorption rate of ∼2800 W g −1 (intrinsic loss power, ILP ∼20.4 W m 2 g −1 kA −2 kHz −1 ) within a high concentration range (collective particle scenario) falling to ∼1000 W g −1 (∼7.9 W m 2 g −1 kA −2 kHz −1 ) on full dispersion by dilution. The effect of stabilising ligand surface chemistry on the concentration-dependent hyperthermic and MRI efficacies was evaluated by ligand exchange/phase transfer from organic to aqueous and back to organic suspension, and on the formation of organogels. Fast field-cycling NMR relaxometry of the different suspensions reveals the role of moment dynamics and of subtle differences in particle and solvent diffusion in determining both the hyperthermic and relaxometric efficacies. These insights identify particle design compromises that are required to simultaneously optimise MNPs for the two applications. Changes in hyperthermic and MRI efficacies of magnetic nanoparticle suspensions following ligand exchange/phase transfer and in the gel phase reveals how the responses are determined by moment dynamics and particle and solvent diffusion.