NMR analysis of N-labeled naphthyridine carbamate dimer (NCD) to contiguous CGG/CGG units in DNA

The structure of the complex formed by naphthyridine carbamate dimer (NCD) binding to CGG repeat sequences in DNA, associated with fragile X syndrome, has been elucidated using 15 N-labeled NCD and 1 H- 15 N HSQC. In a fully saturated state, two NCD molecules consistently bind to each CGG/CGG unit,...

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2024-03, Vol.6 (27), p.3645-3648
Main Authors: Yamada, Takeshi, Sakurabayashi, Shuhei, Sugiura, Noriaki, Haneoka, Hitoshi, Nakatani, Kazuhiko
Format: Article
Language:English
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Summary:The structure of the complex formed by naphthyridine carbamate dimer (NCD) binding to CGG repeat sequences in DNA, associated with fragile X syndrome, has been elucidated using 15 N-labeled NCD and 1 H- 15 N HSQC. In a fully saturated state, two NCD molecules consistently bind to each CGG/CGG unit, maintaining a 1 : 2 binding stoichiometry. The structure of the complex formed by naphthyridine carbamate dimer (NCD) binding to CGG repeat sequences in DNA, associated with fragile X syndrome, has been elucidated using 15 N-labeled NCD and 1 H- 15 N HSQC.
ISSN:1359-7345
1364-548X
DOI:10.1039/d4cc00544a