Photoredox-catalyzed alkylarylation of activated alkenes a ring-opening/Truce-Smiles rearrangement cascade

A photoredox-catalyzed alkylarylation of activated alkenes via a radical C-C bond cleavage/Truce-Smiles rearrangement cascade is developed. The protocol features mild and redox-neutral conditions, broad substrate scope and excellent functional group compatibility, providing a facile and efficient ap...

Full description

Saved in:
Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2024-05, Vol.6 (4), p.5334-5337
Main Authors: Zhang, Jin-Hua, Miao, Hong-Jie, Xin, Hong, Wang, Gang, Yang, Xiaoyu, Wang, Xianjun, Gao, Pin, Duan, Xin-Hua, Guo, Li-Na
Format: Article
Language:
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:A photoredox-catalyzed alkylarylation of activated alkenes via a radical C-C bond cleavage/Truce-Smiles rearrangement cascade is developed. The protocol features mild and redox-neutral conditions, broad substrate scope and excellent functional group compatibility, providing a facile and efficient approach to the long-chain distal keto-amides with all-carbon quaternary centers at the alpha position. A photoredox-catalyzed alkylarylation of activated alkenes via a ring-opening/Truce-Smiles rearrangement cascade is developed. The protocol features broad substrate scope and excellent functional group compatibility.
ISSN:1359-7345
1364-548X
DOI:10.1039/d4cc01324g