Alkylation of amines with primary/secondary alcohols using a novel cobalt() inverse triazolyl-pyridine complex

Herein, we report a highly effective homogeneous methodology for the N -alkylation of amines with primary and secondary alcohols using a Co( ii )-complex of an inverse triazolyl-pyridine ligand. The developed methodology tolerates various functional groups to produce the desired N -alkylated product...

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Published in:Chemical communications (Cambridge, England) England), 2024-08, Vol.6 (65), p.8581-8584
Main Authors: Shekhawat, Bhawana, Gahlaut, Puneet Singh, Gautam, Deepak, Jana, Barun
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Summary:Herein, we report a highly effective homogeneous methodology for the N -alkylation of amines with primary and secondary alcohols using a Co( ii )-complex of an inverse triazolyl-pyridine ligand. The developed methodology tolerates various functional groups to produce the desired N -alkylated products in up to 98% yield. A number of control experiments establish that the developed methodology follows a hydrogen auto-transfer (HAT) pathway. Herein, we report a highly effective homogeneous methodology for the N -alkylation of amines with primary and secondary alcohols using a Co( ii )-complex of an inverse triazolyl-pyridine ligand.
ISSN:1359-7345
1364-548X
DOI:10.1039/d4cc01996b