Visible light-mediated difluoromethylation/cyclization in batch and flow: scalable synthesis of CHF-containing benzimidazo- and indolo[2,1-]isoquinolin-6(5)-ones

We report here a practical and cost-effective method for the synthesis of CHF 2 -containing benzimidazo- and indolo[2,1, a ]-isoquinolin-6(5 H )-ones through a visible light-mediated difluoromethylation/cyclization cascade. The method, which affords functionalized multifused N-heterocyclic scaffolds...

Full description

Saved in:
Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2024-07, Vol.6 (61), p.7938-7941
Main Authors: Hannam, Al, Kankraisri, Phinyada, Thombare, Karan R, Meher, Prahallad, Jean, Alexandre, Hilton, Stephen T, Murarka, Sandip, Arseniyadis, Stellios
Format: Article
Language:
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:We report here a practical and cost-effective method for the synthesis of CHF 2 -containing benzimidazo- and indolo[2,1, a ]-isoquinolin-6(5 H )-ones through a visible light-mediated difluoromethylation/cyclization cascade. The method, which affords functionalized multifused N-heterocyclic scaffolds in moderate to high yields under mild reaction conditions, is also easily scalable using low-cost 3D printed photoflow reactors. We report here a practical and cost-effective method for the synthesis of CHF 2 -containing benzimidazo- and indolo[2,1, a ]-isoquinolin-6(5 H )-ones through a visible light-mediated difluoromethylation/cyclization cascade.
ISSN:1359-7345
1364-548X
DOI:10.1039/d4cc02557a