Highly stable non-enzymatic glucose sensor based on ternary NiCoFe-layered hydroxide grown on graphene oxide

• Published in: New journal of chemistry 2024-06, Vol.48 (23), p.1739-1747
• Main Authors: Liao, Lumin, Xu, Fen, Sun, Lixian, Luo, Yumei, Guan, Yanxun, Ouyang, Jie, Zeng, Julan, Cao, Zhong, Pan, Hongge, Li, Dianpeng
• Format: Article
• Language: English
• Subjects: Glucose; Graphene; Nanosheets; Saliva; Stability
• ISSN: 1144-0546; 1369-9261
• DOI: 10.1039/d4nj01457j

Here, ternary layer hydroxide (NiCoFe-LDH) nanosheets have been grafted in situ onto graphene oxide (GO) using a one-pot hydrothermal method to obtain NiCoFe-LDH/GO for the fabrication of a non-enzymatic glucose sensor with high stability. SEM analysis shows that ternary LDHs with a nanosheet layer structure grow on GO at an angle with less stacking, thus imparting NiCoFe-LDH/GO with a large specific surface area (112.32 m 2 g −1 ) that exposes more active sites. The results of cyclic voltammetry (CV) and chronoamperometry (CA) studies show that NiCoFe-LDH/GO/GCE displays a wide linear detection range of 0.005-7.54 mM, a sensitivity of 196.18 μA cm −2 mM −1 , and a low detection limit of 0.41 μM (S/N = 3). In particular, NiCoFe-LDH/GO/GCE has high stability, that is, it still holds 90.2% of its initial value even after 90 days. Meanwhile, the study results demonstrate that the NiCoFe-LDH/GO/GCE electrode is suitable for the detection of glucose in artificial saliva, and it also reveals a good recovery ranging from 95.6% to 105.5% in actual saliva. Therefore, NiCoFe-LDH/GO is anticipated to be an ideal sensing material for the creation of noninvasive enzyme-free glucose sensors. Here, ternary layer hydroxide (NiCoFe-LDH) nanosheets have been grafted in situ onto graphene oxide (GO) using a one-pot hydrothermal method to obtain NiCoFe-LDH/GO for the fabrication of a non-enzymatic glucose sensor with high stability.