Organophotocatalytic pyridination of -arylglycines with 4-cyanopyridines by decarboxylative and decyanative radical-radical coupling

A photocatalytic decarboxylative aminoalkylation of 4-cyanopyridines with N -arylglycines is achieved, providing 4-(aminomethyl)pyridine derivatives in moderate to good yields. This organic photocatalytic reaction undergoes a radical-radical cross-coupling process under redox-neutral conditions, fea...

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Published in:Organic & biomolecular chemistry 2024-10, Vol.22 (38), p.786-781
Main Authors: Pan, Changduo, Xiang, Chengli, Yu, Jin-Tao
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Xiang, Chengli
Yu, Jin-Tao
description A photocatalytic decarboxylative aminoalkylation of 4-cyanopyridines with N -arylglycines is achieved, providing 4-(aminomethyl)pyridine derivatives in moderate to good yields. This organic photocatalytic reaction undergoes a radical-radical cross-coupling process under redox-neutral conditions, featuring simple operation, readily available N -arylglycines and a broad substrate scope. Mechanistic investigations indicated that a proton-coupled electron-transfer process was involved to enable the single electron transfer between the reduced photocatalyst and 4-cyanopyridine in the presence of N -arylglycines. A photoredox-catalyzed decarboxylative aminoalkylation of 4-cyanopyridines with N -arylglycines is achieved to provide 4-(aminomethyl)pyridine derivatives through a radical-radical cross-coupling process.
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title Organophotocatalytic pyridination of -arylglycines with 4-cyanopyridines by decarboxylative and decyanative radical-radical coupling
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