Recent advances in site-selective transformations of β-enaminones transition-metal-catalyzed C-H functionalization/annulation

β-Enaminone transformation strategies are widely employed in the synthesis of numerous biologically active drugs and natural products, highlighting their significance in medicinal chemistry. In recent years, various strategies have been developed for synthesizing several five- and six-membered heter...

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Published in:Organic & biomolecular chemistry 2024-12, Vol.23 (1), p.36-58
Main Authors: Roy, Prasanta, Mahato, Karuna, Shrestha, Divya, Mohandoss, Sonaimuthu, Lee, Seung Woo, Lee, Yong Rok
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container_issue 1
container_start_page 36
container_title Organic & biomolecular chemistry
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creator Roy, Prasanta
Mahato, Karuna
Shrestha, Divya
Mohandoss, Sonaimuthu
Lee, Seung Woo
Lee, Yong Rok
description β-Enaminone transformation strategies are widely employed in the synthesis of numerous biologically active drugs and natural products, highlighting their significance in medicinal chemistry. In recent years, various strategies have been developed for synthesizing several five- and six-membered heterocycles, as well as substituted polyaromatic scaffolds, which serve as crucial synthons in drug development, from β-enaminones. Among these approaches, site-selective transformations of β-enaminones via C-H activation and annulation have been particularly well explored. This review summarizes the most recent literature (over the past eight years) on β-enaminone transformations for developing bioactive scaffolds through site-selective C-H bond functionalization and annulation. β-Enaminone transformation strategies are widely employed in the synthesis of numerous biologically active drugs and natural products, highlighting their significance in medicinal chemistry.
doi_str_mv 10.1039/d4ob01612b
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title Recent advances in site-selective transformations of β-enaminones transition-metal-catalyzed C-H functionalization/annulation
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