Novel pyrazoline and pyrazole "turn on" fluorescent sensors selective for Zn/Cd at 480 nm and Fe/Fe at 465 nm in MeCN

A small series of simple pyrazoline and pyrazole based sensors, all derived from the same chalcone precursors, were synthesised, characterised and screened for their fluorescence "turn on" properties in the presence of multiple metals. Pyrazole 8 displayed an excellent fluorescence profile...

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Bibliographic Details
Published in:RSC advances 2024-01, Vol.14 (5), p.3519-3524
Main Author: Ciupa, Alexander
Format: Article
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Summary:A small series of simple pyrazoline and pyrazole based sensors, all derived from the same chalcone precursors, were synthesised, characterised and screened for their fluorescence "turn on" properties in the presence of multiple metals. Pyrazole 8 displayed an excellent fluorescence profile with approx. 20× fold increase in λ em 480 nm with Zn 2+ compared to a 2.5× fold increase with Cd 2+ . Pyrazole 9 displayed a 30× fold increase at λ em 465 nm for Fe 3+ compared to Fe 2+ with a Fe 3+ limit of detection of 0.025 μM. The corresponding pyrazolines displayed contrasting properties with important implications for future pyrazoline and pyrazole sensor design. A small series of simple pyrazoline and pyrazole based sensors, all derived from the same chalcone precursors, were synthesised, characterised and screened for their fluorescence "turn on" properties in the presence of multiple metals.
ISSN:2046-2069
DOI:10.1039/d4ra00036f