Topography hierarchy of biocompatible polyhydroxyalkanoate film

Polyhydroxyalkanoates (PHAs) are used for various biomedical applications due to their biocompatibility. Surface properties, such as surface roughness, are crucial for PHAs performance. Traditional parameters used for the characterization of surface roughness, such as R a , are often insufficient to...

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Bibliographic Details
Published in:RSC advances 2024-06, Vol.14 (27), p.1963-19611
Main Authors: Ghorabe, Fares D. E, Aglikov, Aleksandr, Novikov, Alexander S, Nosonovsky, Michael, Ryltseva, Galina A, Dudaev, Alexey E, Menzianova, Natalia G, Skorb, Ekaterina V, Shishatskaya, Ekaterina I
Format: Article
Language:English
Subjects:
Autocorrelation functions
Biocompatibility
Biomedical materials
Chemistry
Data analysis
Data processing
Polyhydroxyalkanoates
Surface properties
Surface roughness
Thin films
Topography
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Summary:Polyhydroxyalkanoates (PHAs) are used for various biomedical applications due to their biocompatibility. Surface properties, such as surface roughness, are crucial for PHAs performance. Traditional parameters used for the characterization of surface roughness, such as R a , are often insufficient to capture the complex and hierarchical (multiscale) topography of PHA films. We measure the topography and surface roughness of thin PHA films with atomic force microscopy and analyze the topography data using several relatively novel data processing methods, including the calculation of autocorrelation functions, topological data analysis, and the distribution of minimum and maximum values of pixels over the topography data. The results provide details of multiscale and anisotropic surface properties that are crucial to PHAs biocompatibility but often overlooked by traditional topography analysis methods. Synthesis and characterization process of the PHB granules and film.
ISSN:2046-2069
2046-2069
DOI:10.1039/d4ra03398a