Ultrasound-assisted condensation cyclization reaction: fast synthesis of quinazolinones from -aminobenzamides and aldehydes under ambient conditions

• Published in: Reaction chemistry & engineering 2024-12, Vol.1 (1), p.22-26
• Main Authors: Chen, Xuerou, Li, Siqi, Sun, Shilong, Sun, Wuji
• Format: Article
• ISSN: 2058-9883
• DOI: 10.1039/d4re00479e

In this work, a facile and efficient ultrasound-assisted fast synthesis of quinazolinones from o -aminobenzamides and aldehydes is reported. The reaction proceeds smoothly under ambient temperature and pressure conditions without the need for a metal catalyst in just 15 minutes. In addition, this approach exhibits broad substrate tolerance and provides a series of quinazolinones with moderate to excellent yields. The results reported here reveal an important new application of ultrasound-assisted synthesis in the fast synthesis of valuable organic products. Ultrasound irradiation has emerged as a novel and powerful operational approach for the fast synthesis of quinazolinones. The approach was successfully applied under ambient temperature and pressure conditions without the need for a metal catalyst.