Cuproptosis in cancer therapy: mechanisms, therapeutic application and future prospects

Cuproptosis is a regulated form of cell death induced by the accumulation of metal ions and is closely linked to aspects of cellular drug resistance, cellular metabolism, and signalling pathways. Due to its crucial role in regulating physiological and pathological processes, cuproptosis has gained i...

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Published in:Journal of materials chemistry. B, Materials for biology and medicine Materials for biology and medicine, 2024-12, Vol.12 (47), p.12191-1226
Main Authors: Hu, Jiawei, Zhu, Junfei, Chen, Tao, Zhao, Yudie, Xu, Qingwen, Wang, Yan
Format: Article
Language:English
Subjects:
Animals
Antineoplastic Agents - chemistry
Antineoplastic Agents - pharmacology
Antineoplastic Agents - therapeutic use
Antineoplastic drugs
Cancer therapies
Cell death
Chemotherapy
Copper - chemistry
Copper - metabolism
Disulfiram
Disulfiram - chemistry
Disulfiram - pharmacology
Disulfiram - therapeutic use
Drug development
Drug metabolism
Drug resistance
Humans
Metal ions
Neoplasms - drug therapy
Neoplasms - metabolism
Neoplasms - pathology
Signal transduction
Therapy
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Summary:Cuproptosis is a regulated form of cell death induced by the accumulation of metal ions and is closely linked to aspects of cellular drug resistance, cellular metabolism, and signalling pathways. Due to its crucial role in regulating physiological and pathological processes, cuproptosis has gained increasing significance as a potential target for anticancer drug development. In this review, we introduce the definition of cuproptosis and provide a comprehensive discussion of the mechanisms of cuproptosis. In addition, the methods for the detection of cuproptosis are summarized, and recent advances in cuproptosis in cancer therapy are reviewed, mainly in terms of elesclomol (ES)-mediated cuproptosis and disulfiram (DSF)-mediated cuproptosis, which provided practical value for applications. Finally, the current challenges and future development of cuproptosis-mediated cancer therapy are discussed. In summary, this review highlights recent progress on cuproptosis in cancer therapy, offering novel ideas and strategies for future research and applications. Cuproptosis is a regulated form of cell death induced by the accumulation of metal ions and is closely linked to aspects of cellular drug resistance, cellular metabolism, and signalling pathways.
ISSN:2050-750X
2050-7518
2050-7518
DOI:10.1039/d4tb01877j