Vitamin D: a potentially important secosteroid for coping with COVID-19

Abstract COVID-19 is a disease that has caused a high number of deaths in the world, and despite being controlled, it requires attention and the search for new quick and economical therapeutic strategies. In this sense, vitamin D stands out, an immunomodulator that has shown beneficial effects in de...

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Bibliographic Details
Published in:Anais da Academia Brasileira de Ciências 2022, Vol.94 (2), p.e20201545-e20201545
Main Authors: ARAÚJO, THAYANNE S.S., SANTOS, COSME S., SOARES, JULIANA K.B., FREITAS, JULIANO C.R.
Format: Article
Language:English
Subjects:
MULTIDISCIPLINARY SCIENCES
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Summary:Abstract COVID-19 is a disease that has caused a high number of deaths in the world, and despite being controlled, it requires attention and the search for new quick and economical therapeutic strategies. In this sense, vitamin D stands out, an immunomodulator that has shown beneficial effects in decreasing the risk and severity of acute respiratory tract infections, including COVID-19. Therefore, this review presents a number of experimental, observational and clinical studies on the importance of vitamin D against viral infections with an emphasis on COVID-19, highlighting the relationship between vitamin D, Renin-Angiotensin System and cytokine storms with decreased inflammatory lesions in patients with COVID-19. In addition, aspects of pathophysiology, metabolism, risk factors, sources and recommendations of vitamin D are described. We conclude that vitamin D plays a protective role against inflammatory lesions and can decrease the risk of infections and the severity of COVID-19. Therefore, it is essential to maintain adequate levels of vitamin D to avoid complications related to its deficiency.
ISSN:0001-3765
1678-2690
1678-2690
DOI:10.1590/0001-3765202220201545