Transplantation osteoporosis

In the past two decades, there has been a rapid increase in the number of organ transplanted worldwide, including Brazil, along with an improvement in survival and quality of life of the transplant recipients. Osteoporosis and a high incidence of fragility fractures have emerged as a complication of...

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Bibliographic Details
Published in:Arquivos brasileiros de endocrinologia e metabologia 2006-08, Vol.50 (4), p.783-792
Main Authors: Kulak, Carolina A M, Borba, Victoria Z C, Kulak Júnior, Jaime, Shane, Elizabeth
Format: Article
Language:English
Subjects:
Bone and Bones - drug effects
Bone Density
Bone Marrow Transplantation - adverse effects
ENDOCRINOLOGY & METABOLISM
Heart Transplantation - adverse effects
Humans
Immunosuppressive Agents - adverse effects
Kidney Transplantation - adverse effects
Liver Transplantation - adverse effects
Lung Transplantation - adverse effects
Osteoporosis - etiology
Osteoporosis - prevention & control
Transplantation - adverse effects
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Summary:In the past two decades, there has been a rapid increase in the number of organ transplanted worldwide, including Brazil, along with an improvement in survival and quality of life of the transplant recipients. Osteoporosis and a high incidence of fragility fractures have emerged as a complication of organ transplantation. Many factors contribute to the pathogenesis of osteoporosis following organ transplantation. In addition, most patients have some form of bone disease prior to transplantation, which is usually related to adverse effects of end-stage organ failure on the skeleton. This chapter reviews the mechanisms of bone loss that occur both in the early and late post-transplant periods, as well as the features specific to bone loss after kidney, lung, liver, cardiac and bone marrow transplantation. Prevention and treatment for osteoporosis should be instituted prior and in the early and late phase after transplantation, and will also be addressed in this article.
ISSN:0004-2730
1677-9487
0004-2730
DOI:10.1590/S0004-27302006000400023