Analysis of testosterone pulsatility in women with ovulatory menstrual cycles

To evaluate the pattern of the pulsatile secretion of testosterone in normal menstrual cycle. Eight healthy women with ovulatory menstrual cycles were enrolled. Blood samples were collected at ten-minute intervals for six hours, starting between 7 and 8 am, after a ten-hour fasting, in three phases:...

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Bibliographic Details
Published in:Arquivos brasileiros de endocrinologia e metabologia 2009-11, Vol.53 (8), p.1040-1046
Main Authors: Nóbrega, Lucia H C, Azevedo, George D, Lima, Josivan G, Ferriani, Rui A, Spritzer, Poli Mara, Sá, Marcos F S, Maranhão, Técia M O
Format: Article
Language:English
Subjects:
Adolescent
Adult
Analysis of Variance
ENDOCRINOLOGY & METABOLISM
Female
Humans
Luteinizing Hormone - blood
Menstrual Cycle - blood
Menstrual Cycle - physiology
Periodicity
Statistics, Nonparametric
Testosterone - blood
Young Adult
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Summary:To evaluate the pattern of the pulsatile secretion of testosterone in normal menstrual cycle. Eight healthy women with ovulatory menstrual cycles were enrolled. Blood samples were collected at ten-minute intervals for six hours, starting between 7 and 8 am, after a ten-hour fasting, in three phases: mid-follicular (Day 7), late follicular (Day 12) and mid-luteal phase (Day 21). Samples were assayed for testosterone, LH and the baseline also for SHBG. Testosterone pulse frequency, mean amplitude pulse, percentage of increment in pulse amplitude, mean duration of pulses and pulse interval were similar in the three phases. LH pulsatility was statistically different among the three phases (p < 0.001) representing normal ovulatory cycles. These data increase the knowledge about the testosterone secretion profile in the human menstrual cycle and can be used as a contribution to clinical investigation in both hyperandrogenism and androgen insufficiency syndrome.
ISSN:0004-2730
1677-9487
1677-9487
0004-2730
DOI:10.1590/S0004-27302009000800020