The brazilian version of the Quality of Life Assessment of Growth Hormone Deficiency in Adults (QoL-AGHDA): Four-stage translation and validation

• Published in: Arquivos brasileiros de endocrinologia e metabologia 2010-12, Vol.54 (9), p.833-841
• Main Authors: Ribeiro-Oliveira, Jr, Antônio, Mol, Suélem Simão, Twiss, James, Alencar, Guilherme Asmar, Miranda, Paulo Augusto Carvalho, Naves, Luciana A, Azevedo, Monalisa F, Basílio, Flávia M A, Boguszewski, César Luiz, Nogueira, Kátia C, Vilar, Lúcio, Koltowska-Haggstrom, Maria, McKenna, Steve P
• Format: Article
• Language: English
• Subjects: Adult; Brazil; ENDOCRINOLOGY & METABOLISM; Female; Human Growth Hormone - deficiency; Humans; Language; Male; Middle Aged; Quality of Life; Reproducibility of Results; Statistics, Nonparametric; Surveys and Questionnaires - standards; Translations
• ISSN: 0004-2730; 1677-9487; 1677-9487; 0004-2730
• DOI: 10.1590/S0004-27302010000900010

This study reports on the Brazilian Portuguese adaptation of the QoL-AGHDA (Quality of Life Assessment of Growth Hormone Deficiency in Adults) for use in adult growth hormone deficient (GHD) patients. The translation process adopted the dual panel methodology. The questionnaire was tested through field-test interviews (16 GHD patients). In the final stage, data from 120 GHD patients (81 included in a test-retest analysis) were analyzed for internal consistency, test-retest reliability, convergent validity and validity among known groups. The translation panels were successful and the draft version was amended to improve the wording as a result of the field-test interviews. Cronbach's alpha was 0.90 and test-retest reliability 0.88. QoL-AGHDA scores had the expected pattern of association with NHP scale scores and QoL-AGHDA was able to differentiate significantly between patients based on patient-reported general health (p < 0.01) and QoL (p < 0.01). The adaptation of the QoL-AGHDA for a Brazilian population was successful and the adapted questionnaire was shown to be reliable and valid.