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Is thyroid stunning clinically relevant? A retrospective analysis of 208 patients

Current guidelines have advised against the performance of (131)I-iodide diagnostic whole body scintigraphy (dxWBS) to minimize the occurrence of stunning, and to guarantee the efficiency of radioiodine therapy (RIT). The aim of the study was to evaluate the impact of stunning on the efficacy of RIT...

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Published in:Arquivos brasileiros de endocrinologia e metabologia 2014-04, Vol.58 (3), p.292-300
Main Authors: Etchebehere, Elba C S C, Santos, Allan O, Matos, Patrícia S, Assumpção, Lígia V M, Lima, Maria Cecília V L, Lima, Mariana C L, Ward, Laura S
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creator Etchebehere, Elba C S C
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description Current guidelines have advised against the performance of (131)I-iodide diagnostic whole body scintigraphy (dxWBS) to minimize the occurrence of stunning, and to guarantee the efficiency of radioiodine therapy (RIT). The aim of the study was to evaluate the impact of stunning on the efficacy of RIT and disease outcome. This retrospective analysis included 208 patients with differentiated thyroid cancer managed according to a same protocol and followed up for 12-159 months (mean 30 ± 69 months). Patients received RIT in doses ranging from 3,700 to 11,100 MBq (100 mCi to 300 mCi). Post-RIT-whole body scintigraphy images were performed 10 days after RIT in all patients. In addition, images were also performed 24-48 hours after therapy in 22 patients. Outcome was classified as no evidence of disease (NED), stable disease (SD) and progressive disease (PD). Thyroid stunning occurred in 40 patients (19.2%), including 26 patients with NED and 14 patients with SD. A multivariate analysis showed no association between disease outcome and the occurrence of stunning (p = 0.3476). The efficacy of RIT and disease outcome do not seem to be related to thyroid stunning.
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subjects Adenocarcinoma, Follicular - radiotherapy
Adult
Carcinoma, Papillary - radiotherapy
Disease Progression
ENDOCRINOLOGY & METABOLISM
Female
Humans
Iodine Radioisotopes - administration & dosage
Iodine Radioisotopes - therapeutic use
Male
Middle Aged
Multivariate Analysis
Radionuclide Imaging
Retrospective Studies
Thyroid Gland - diagnostic imaging
Thyroid Gland - surgery
Thyroid Neoplasms - classification
Thyroid Neoplasms - radiotherapy
Thyroidectomy
Treatment Outcome
Whole Body Imaging
title Is thyroid stunning clinically relevant? A retrospective analysis of 208 patients
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