Evaluation of parathyroid function and mineral metabolism in psychiatric patients using lithium salts

To evaluate parathyroid function and mineral metabolism in psychiatric patients users of lithium salts. We measured the serum levels of calcium, ionized calcium, inorganic phosphorus, alkaline phosphatase, albumin, parathyroid hormone (PTH), urea, creatinine, 25-hydroxy-vitamin D and lithium of 35 p...

Full description

Saved in:
Bibliographic Details
Published in:Arquivos brasileiros de endocrinologia e metabologia 2014-08, Vol.58 (6), p.619-624
Main Authors: Oliveira, Thiago Costa de, Campos Neto, Ivo Alves de, Aguiar-Oliveira, Manuel Hermínio de, Pereira, Francisco de Assis
Format: Article
Language:English
Subjects:
Adult
Aged
Alkaline Phosphatase - blood
Bipolar Disorder - drug therapy
Bipolar Disorder - metabolism
Calcium - blood
Case-Control Studies
Creatinine - blood
Cross-Sectional Studies
ENDOCRINOLOGY & METABOLISM
Female
Humans
Hyperparathyroidism, Secondary - diagnosis
Lithium Compounds - blood
Lithium Compounds - therapeutic use
Male
Mental Disorders - drug therapy
Mental Disorders - metabolism
Middle Aged
Minerals - metabolism
Parathyroid Glands - drug effects
Parathyroid Glands - physiology
Parathyroid Hormone - blood
Phosphorus - blood
Serum Albumin - analysis
Urea - blood
Vitamin D - analogs & derivatives
Vitamin D - blood
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:To evaluate parathyroid function and mineral metabolism in psychiatric patients users of lithium salts. We measured the serum levels of calcium, ionized calcium, inorganic phosphorus, alkaline phosphatase, albumin, parathyroid hormone (PTH), urea, creatinine, 25-hydroxy-vitamin D and lithium of 35 patients diagnosed with bipolar disorder in use of lithium carbonate (LC) for at least one year (Lithium Group - LG) and 35 healthy subjects (Control Group - CG). The LG and CG were matched by sex and age. There was only statistic difference in relation to the levels of PTH and ionized calcium, with p < 0.004 and p < 0.03, respectively. Secondary form of hyperparathyroidism (HPT) was found in eight (22.8%) LG patients and in none of the CG. There was no correlation between lithemia, usage time and dosage of LC. Our data demonstrate that lithium may create an imbalance in the parathyroid axis, characterized by elevated levels of PTH.
ISSN:0004-2730
1677-9487
1677-9487
0004-2730
DOI:10.1590/0004-2730000002983