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Evaluation of parathyroid function and mineral metabolism in psychiatric patients using lithium salts
To evaluate parathyroid function and mineral metabolism in psychiatric patients users of lithium salts. We measured the serum levels of calcium, ionized calcium, inorganic phosphorus, alkaline phosphatase, albumin, parathyroid hormone (PTH), urea, creatinine, 25-hydroxy-vitamin D and lithium of 35 p...
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| Published in: | Arquivos brasileiros de endocrinologia e metabologia 2014-08, Vol.58 (6), p.619-624 |
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| container_title | Arquivos brasileiros de endocrinologia e metabologia |
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| creator | Oliveira, Thiago Costa de Campos Neto, Ivo Alves de Aguiar-Oliveira, Manuel Hermínio de Pereira, Francisco de Assis |
| description | To evaluate parathyroid function and mineral metabolism in psychiatric patients users of lithium salts.
We measured the serum levels of calcium, ionized calcium, inorganic phosphorus, alkaline phosphatase, albumin, parathyroid hormone (PTH), urea, creatinine, 25-hydroxy-vitamin D and lithium of 35 patients diagnosed with bipolar disorder in use of lithium carbonate (LC) for at least one year (Lithium Group - LG) and 35 healthy subjects (Control Group - CG).
The LG and CG were matched by sex and age. There was only statistic difference in relation to the levels of PTH and ionized calcium, with p < 0.004 and p < 0.03, respectively. Secondary form of hyperparathyroidism (HPT) was found in eight (22.8%) LG patients and in none of the CG. There was no correlation between lithemia, usage time and dosage of LC.
Our data demonstrate that lithium may create an imbalance in the parathyroid axis, characterized by elevated levels of PTH. |
| doi_str_mv | 10.1590/0004-2730000002983 |
| format | article |
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We measured the serum levels of calcium, ionized calcium, inorganic phosphorus, alkaline phosphatase, albumin, parathyroid hormone (PTH), urea, creatinine, 25-hydroxy-vitamin D and lithium of 35 patients diagnosed with bipolar disorder in use of lithium carbonate (LC) for at least one year (Lithium Group - LG) and 35 healthy subjects (Control Group - CG).
The LG and CG were matched by sex and age. There was only statistic difference in relation to the levels of PTH and ionized calcium, with p < 0.004 and p < 0.03, respectively. Secondary form of hyperparathyroidism (HPT) was found in eight (22.8%) LG patients and in none of the CG. There was no correlation between lithemia, usage time and dosage of LC.
Our data demonstrate that lithium may create an imbalance in the parathyroid axis, characterized by elevated levels of PTH.</description><identifier>ISSN: 0004-2730</identifier><identifier>ISSN: 1677-9487</identifier><identifier>EISSN: 1677-9487</identifier><identifier>EISSN: 0004-2730</identifier><identifier>DOI: 10.1590/0004-2730000002983</identifier><identifier>PMID: 25211444</identifier><language>eng</language><publisher>Brazil: Sociedade Brasileira de Endocrinologia e Metabologia</publisher><subject>Adult ; Aged ; Alkaline Phosphatase - blood ; Bipolar Disorder - drug therapy ; Bipolar Disorder - metabolism ; Calcium - blood ; Case-Control Studies ; Creatinine - blood ; Cross-Sectional Studies ; ENDOCRINOLOGY & METABOLISM ; Female ; Humans ; Hyperparathyroidism, Secondary - diagnosis ; Lithium Compounds - blood ; Lithium Compounds - therapeutic use ; Male ; Mental Disorders - drug therapy ; Mental Disorders - metabolism ; Middle Aged ; Minerals - metabolism ; Parathyroid Glands - drug effects ; Parathyroid Glands - physiology ; Parathyroid Hormone - blood ; Phosphorus - blood ; Serum Albumin - analysis ; Urea - blood ; Vitamin D - analogs & derivatives ; Vitamin D - blood</subject><ispartof>Arquivos brasileiros de endocrinologia e metabologia, 2014-08, Vol.58 (6), p.619-624</ispartof><rights>This work is licensed under a Creative Commons Attribution-NonCommercial 3.0 International License.</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c386t-168da22e5b4797c3bbe6c7fc2bff6994123c561a141218a3013fec43ac1331553</citedby><cites>FETCH-LOGICAL-c386t-168da22e5b4797c3bbe6c7fc2bff6994123c561a141218a3013fec43ac1331553</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,777,781,882,24131,27905,27906</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25211444$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Oliveira, Thiago Costa de</creatorcontrib><creatorcontrib>Campos Neto, Ivo Alves de</creatorcontrib><creatorcontrib>Aguiar-Oliveira, Manuel Hermínio de</creatorcontrib><creatorcontrib>Pereira, Francisco de Assis</creatorcontrib><title>Evaluation of parathyroid function and mineral metabolism in psychiatric patients using lithium salts</title><title>Arquivos brasileiros de endocrinologia e metabologia</title><addtitle>Arq Bras Endocrinol Metabol</addtitle><description>To evaluate parathyroid function and mineral metabolism in psychiatric patients users of lithium salts.
We measured the serum levels of calcium, ionized calcium, inorganic phosphorus, alkaline phosphatase, albumin, parathyroid hormone (PTH), urea, creatinine, 25-hydroxy-vitamin D and lithium of 35 patients diagnosed with bipolar disorder in use of lithium carbonate (LC) for at least one year (Lithium Group - LG) and 35 healthy subjects (Control Group - CG).
The LG and CG were matched by sex and age. There was only statistic difference in relation to the levels of PTH and ionized calcium, with p < 0.004 and p < 0.03, respectively. Secondary form of hyperparathyroidism (HPT) was found in eight (22.8%) LG patients and in none of the CG. There was no correlation between lithemia, usage time and dosage of LC.
Our data demonstrate that lithium may create an imbalance in the parathyroid axis, characterized by elevated levels of PTH.</description><subject>Adult</subject><subject>Aged</subject><subject>Alkaline Phosphatase - blood</subject><subject>Bipolar Disorder - drug therapy</subject><subject>Bipolar Disorder - metabolism</subject><subject>Calcium - blood</subject><subject>Case-Control Studies</subject><subject>Creatinine - blood</subject><subject>Cross-Sectional Studies</subject><subject>ENDOCRINOLOGY & METABOLISM</subject><subject>Female</subject><subject>Humans</subject><subject>Hyperparathyroidism, Secondary - diagnosis</subject><subject>Lithium Compounds - blood</subject><subject>Lithium Compounds - therapeutic use</subject><subject>Male</subject><subject>Mental Disorders - drug therapy</subject><subject>Mental Disorders - metabolism</subject><subject>Middle Aged</subject><subject>Minerals - metabolism</subject><subject>Parathyroid Glands - drug effects</subject><subject>Parathyroid Glands - physiology</subject><subject>Parathyroid Hormone - blood</subject><subject>Phosphorus - blood</subject><subject>Serum Albumin - analysis</subject><subject>Urea - blood</subject><subject>Vitamin D - analogs & derivatives</subject><subject>Vitamin D - blood</subject><issn>0004-2730</issn><issn>1677-9487</issn><issn>1677-9487</issn><issn>0004-2730</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><recordid>eNo9kUtPAyEUhYnRaK3-AReGpZtRLjAPlsb4SkxcqGvCUMbSMFCBMem_l1otIeFecr57knsQugByDbUgN4QQXtGWkd9DRccO0Ayatq0E79pDNNsLTtBpSqui4ULQY3RCawrAOZ8hc_-t3KSyDR6HAa9VVHm5icEu8DB5_fuv_AKP1puoHB5NVn1wNo3YerxOG720KkerC5qt8TnhKVn_iZ3NSzuNOCmX0xk6GpRL5vzvnaOPh_v3u6fq5fXx-e72pdKsa3IFTbdQlJq6561oNet70-h20LQfhkYIDpTpugEFpYJOMQJsMJozpYExqGs2R9e7uUlb44JchSn6YijftquQ21VQArw0TbkgCnC1A9YxfE0mZTnapI1zypswJQnFTrSk4bRI6U6qY0gpmkGuox1V3EggcpuH3Hvs8yjQ5d_8qR_NYo_8B8B-ABkWg7w</recordid><startdate>20140801</startdate><enddate>20140801</enddate><creator>Oliveira, Thiago Costa de</creator><creator>Campos Neto, Ivo Alves de</creator><creator>Aguiar-Oliveira, Manuel Hermínio de</creator><creator>Pereira, Francisco de Assis</creator><general>Sociedade Brasileira de Endocrinologia e Metabologia</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>GPN</scope></search><sort><creationdate>20140801</creationdate><title>Evaluation of parathyroid function and mineral metabolism in psychiatric patients using lithium salts</title><author>Oliveira, Thiago Costa de ; Campos Neto, Ivo Alves de ; Aguiar-Oliveira, Manuel Hermínio de ; Pereira, Francisco de Assis</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c386t-168da22e5b4797c3bbe6c7fc2bff6994123c561a141218a3013fec43ac1331553</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Alkaline Phosphatase - blood</topic><topic>Bipolar Disorder - drug therapy</topic><topic>Bipolar Disorder - metabolism</topic><topic>Calcium - blood</topic><topic>Case-Control Studies</topic><topic>Creatinine - blood</topic><topic>Cross-Sectional Studies</topic><topic>ENDOCRINOLOGY & METABOLISM</topic><topic>Female</topic><topic>Humans</topic><topic>Hyperparathyroidism, Secondary - diagnosis</topic><topic>Lithium Compounds - blood</topic><topic>Lithium Compounds - therapeutic use</topic><topic>Male</topic><topic>Mental Disorders - drug therapy</topic><topic>Mental Disorders - metabolism</topic><topic>Middle Aged</topic><topic>Minerals - metabolism</topic><topic>Parathyroid Glands - drug effects</topic><topic>Parathyroid Glands - physiology</topic><topic>Parathyroid Hormone - blood</topic><topic>Phosphorus - blood</topic><topic>Serum Albumin - analysis</topic><topic>Urea - blood</topic><topic>Vitamin D - analogs & derivatives</topic><topic>Vitamin D - blood</topic><toplevel>online_resources</toplevel><creatorcontrib>Oliveira, Thiago Costa de</creatorcontrib><creatorcontrib>Campos Neto, Ivo Alves de</creatorcontrib><creatorcontrib>Aguiar-Oliveira, Manuel Hermínio de</creatorcontrib><creatorcontrib>Pereira, Francisco de Assis</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>SciELO</collection><jtitle>Arquivos brasileiros de endocrinologia e metabologia</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Oliveira, Thiago Costa de</au><au>Campos Neto, Ivo Alves de</au><au>Aguiar-Oliveira, Manuel Hermínio de</au><au>Pereira, Francisco de Assis</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Evaluation of parathyroid function and mineral metabolism in psychiatric patients using lithium salts</atitle><jtitle>Arquivos brasileiros de endocrinologia e metabologia</jtitle><addtitle>Arq Bras Endocrinol Metabol</addtitle><date>2014-08-01</date><risdate>2014</risdate><volume>58</volume><issue>6</issue><spage>619</spage><epage>624</epage><pages>619-624</pages><issn>0004-2730</issn><issn>1677-9487</issn><eissn>1677-9487</eissn><eissn>0004-2730</eissn><abstract>To evaluate parathyroid function and mineral metabolism in psychiatric patients users of lithium salts.
We measured the serum levels of calcium, ionized calcium, inorganic phosphorus, alkaline phosphatase, albumin, parathyroid hormone (PTH), urea, creatinine, 25-hydroxy-vitamin D and lithium of 35 patients diagnosed with bipolar disorder in use of lithium carbonate (LC) for at least one year (Lithium Group - LG) and 35 healthy subjects (Control Group - CG).
The LG and CG were matched by sex and age. There was only statistic difference in relation to the levels of PTH and ionized calcium, with p < 0.004 and p < 0.03, respectively. Secondary form of hyperparathyroidism (HPT) was found in eight (22.8%) LG patients and in none of the CG. There was no correlation between lithemia, usage time and dosage of LC.
Our data demonstrate that lithium may create an imbalance in the parathyroid axis, characterized by elevated levels of PTH.</abstract><cop>Brazil</cop><pub>Sociedade Brasileira de Endocrinologia e Metabologia</pub><pmid>25211444</pmid><doi>10.1590/0004-2730000002983</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| source | SciELO |
| subjects | Adult Aged Alkaline Phosphatase - blood Bipolar Disorder - drug therapy Bipolar Disorder - metabolism Calcium - blood Case-Control Studies Creatinine - blood Cross-Sectional Studies ENDOCRINOLOGY & METABOLISM Female Humans Hyperparathyroidism, Secondary - diagnosis Lithium Compounds - blood Lithium Compounds - therapeutic use Male Mental Disorders - drug therapy Mental Disorders - metabolism Middle Aged Minerals - metabolism Parathyroid Glands - drug effects Parathyroid Glands - physiology Parathyroid Hormone - blood Phosphorus - blood Serum Albumin - analysis Urea - blood Vitamin D - analogs & derivatives Vitamin D - blood |
| title | Evaluation of parathyroid function and mineral metabolism in psychiatric patients using lithium salts |
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