Orbital mucosa-associated lymphoid tissue (MALT) lymphoma as the initial presentation in patients with hepatitis C virus infection

Hepatitis C virus infection may be implicated in 12.7% of ocular adnexal marginal zone lymphomas. We present the first case of an orbital-systemic mucosa-associated lymphoid tissue lymphoma that responded to hepatitis C virus medical treatment. A 62-year-old male with a right-sided orbital mass was...

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Bibliographic Details
Published in:Arquivos brasileiros de oftalmologia 2024-01, Vol.87 (2), p.e20220091
Main Authors: Lloreda-Martin, Leyre, Berrocal-Cuadrado, Ana, Torres Nieto, Maria Angeles, Galindo-Ferreiro, Alicia
Format: Article
Language:English
Subjects:
Case Report
Hepacivirus
Hepatitis C - complications
Hepatitis C - drug therapy
Humans
Lymphoid Tissue
Lymphoma, B-Cell, Marginal Zone - complications
Lymphoma, B-Cell, Marginal Zone - drug therapy
Male
Middle Aged
Mucous Membrane
OPHTHALMOLOGY
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Summary:Hepatitis C virus infection may be implicated in 12.7% of ocular adnexal marginal zone lymphomas. We present the first case of an orbital-systemic mucosa-associated lymphoid tissue lymphoma that responded to hepatitis C virus medical treatment. A 62-year-old male with a right-sided orbital mass was diagnosed with stage IIA orbital marginal zone lymphoma in addition to hepatitis C virus infection based on clinical, imaging, laboratory, and histological examinations. The systemic and orbital responses were achieved 1 year after undergoing hepatitis C virus treatment with glecaprevir/pibrentasvir. The association between the hepatitis C virus infection and orbital-systemic mucosa-associated lymphoid tissue lymphoma is relevant. Accordingly, patients with orbital mucosa-associated lymphoid tissue lymphoma should be assessed for hepatitis C virus seroreactivity for therapeutic and prognostic purposes.
ISSN:0004-2749
1678-2925
1678-2925
DOI:10.5935/0004-2749.2022-0091