Guardians of the ocular surface: lessons learned from a challenging case of Langerhans cell histiocytosis with eyelid involvement

Langerhans cell histiocytosis comprises a heterogeneous range of clinical manifestations secondary to clonal proliferation of histiocytes, characterized by the accumulation of these cells in various organs and tissues. The ophthalmological component commonly involved is the orbit. Herein, we report...

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Bibliographic Details
Published in:Arquivos brasileiros de oftalmologia 2025-01, Vol.88 (2), p.e20240007-4
Main Authors: Cyrino, Laura Goldfarb, Cesar, Andrea Santucci, Zumblick, Lia, Kato, Juliana, Picciarelli, Patricia, Santo, Ruth Miyuki
Format: Article
Language:English
Subjects:
Diagnosis, Differential
Eyelid Diseases - etiology
Eyelid Diseases - pathology
Female
Histiocytosis, Langerhans-Cell - pathology
Humans
Male
OPHTHALMOLOGY
Quality of Life
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Summary:Langerhans cell histiocytosis comprises a heterogeneous range of clinical manifestations secondary to clonal proliferation of histiocytes, characterized by the accumulation of these cells in various organs and tissues. The ophthalmological component commonly involved is the orbit. Herein, we report a rare case of Langerhans cell histiocytosis with eyelid involvement, which resulted in severe ocular surface complications, which subsequently significantly impacted the patient's quality of life. This case report highlights the fact that despite being rare, Langerhans cell histiocytosis should be included in the differential diagnosis of eyelid lesions. Furthermore, a multidisciplinary approach with a systemic overview is crucial for managing the ocular complications.
ISSN:0004-2749
1678-2925
1678-2925
DOI:10.5935/0004-2749.2024-0007