The value of CSF analysis for the differential diagnosis of HTLV-I associated myelopathy and multiple sclerosis

Cerebrospinal fluid (CSF) and serum of 17 patients with HAM/TSP (HTLV-I associated myelopathy/tropical spastic paraparesis), six with multiple sclerosis and six with idiopathic epilepsy (non inflammatory control) from Brazil were analysed for the presence of intrathecal synthesis of virus-specific a...

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Bibliographic Details
Published in:Arquivos de neuro-psiquiatria 1995-12, Vol.53 (4), p.760-765
Main Authors: Puccioni-Sohler, M, Kitze, B, Felgenhauer, K, Graef, I T, Lange, P, Novis, S, Reiber, H, Vaz, B
Format: Article
Language:English
Subjects:
AIDS/HIV
Brazil
Diagnosis, Differential
Epilepsy - blood
Epilepsy - cerebrospinal fluid
Epilepsy - immunology
Epilepsy - virology
HTLV-I Antibodies - blood
HTLV-I Antibodies - cerebrospinal fluid
Humans
Multiple Sclerosis - blood
Multiple Sclerosis - cerebrospinal fluid
Multiple Sclerosis - immunology
Multiple Sclerosis - virology
NEUROSCIENCES
Paraparesis, Tropical Spastic - blood
Paraparesis, Tropical Spastic - cerebrospinal fluid
Paraparesis, Tropical Spastic - immunology
Paraparesis, Tropical Spastic - virology
PSYCHIATRY
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Summary:Cerebrospinal fluid (CSF) and serum of 17 patients with HAM/TSP (HTLV-I associated myelopathy/tropical spastic paraparesis), six with multiple sclerosis and six with idiopathic epilepsy (non inflammatory control) from Brazil were analysed for the presence of intrathecal synthesis of virus-specific antibodies against measles, rubella, varicella zoster virus and herpes simplex virus by enzyme-linked immunosorbent assay (ELISA). All HAM/TSP and multiple sclerosis cases had an intrathecal immune response (oligoclonal IgG). In HAM/TSP, only 1/17 case showed a polyspecific intrathecal immune response against measles and rubella virus. In multiple sclerosis, specific antibodies against measles and rubella (MRZ response) were observed in all patients but not in the control with idiopathic epilepsy. The diagnostic and theoretical relevance of mono- and polyspecific immune responses is discussed for these chronic neurological diseases.
ISSN:0004-282X
1678-4227
0004-282X
DOI:10.1590/S0004-282X1995000500008