Myoclonic epilepsy of late onset in trisomy 21

We report the case of a patient with trisomy 21 (T21) with late onset epilepsy. The electroclinical features were of myoclonic jerks on awakening and generalised tonic clonic seizures, with generalised spike and wave on EEG, and a progressive dementia. As familial Alzheimer's dementia and progr...

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Bibliographic Details
Published in:Arquivos de neuro-psiquiatria 1995-12, Vol.53 (4), p.792-794
Main Authors: Li, L M, O'Donoghue, M F, Sander, J W
Format: Article
Language:English
Subjects:
Down Syndrome - complications
Epilepsies, Myoclonic - etiology
Humans
Male
Middle Aged
NEUROSCIENCES
PSYCHIATRY
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Summary:We report the case of a patient with trisomy 21 (T21) with late onset epilepsy. The electroclinical features were of myoclonic jerks on awakening and generalised tonic clonic seizures, with generalised spike and wave on EEG, and a progressive dementia. As familial Alzheimer's dementia and progressive myoclonic epilepsy (Unverricht-Lundborg type) are both linked to the chromosome 21, this case may represent a distinct progressive myoclonic epilepsy related to T21.
ISSN:0004-282X
1678-4227
0004-282X
DOI:10.1590/s0004-282x1995000500014