Tuberculosis: an uncommon cause of cerebral venous thrombosis?

Several infectious etiologies are related to cerebral venous thrombosis (CVT), but a review of literature showed only few cases related to tuberculosis (TB), and only one with neurological manifestations. We report an unusual case of CVT related to TB and mutation in prothrombin gene. A 38-man black...

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Bibliographic Details
Published in:Arquivos de neuro-psiquiatria 2005-09, Vol.63 (3B), p.852-854
Main Authors: Fiorot Júnior, José Antonio, Felício, André Carvalho, Fukujima, Márcia Mauimi, Rodrigues, Celso Arraes, Morelli, Vânia Maria, Lourenço, Dayse Maria, Prado, Gilmar Fernandes do
Format: Article
Language:English
Subjects:
Adult
Humans
Intracranial Thrombosis - microbiology
Magnetic Resonance Imaging
Male
Mycobacterium
NEUROSCIENCES
Point Mutation
Prothrombin - genetics
PSYCHIATRY
Tuberculosis, Central Nervous System - complications
Venous Thrombosis - microbiology
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Summary:Several infectious etiologies are related to cerebral venous thrombosis (CVT), but a review of literature showed only few cases related to tuberculosis (TB), and only one with neurological manifestations. We report an unusual case of CVT related to TB and mutation in prothrombin gene. A 38-man black presented abrupt right hemiparestesis, and hemiparesis. Investigations revealed CVT. Cerebral spinal fluid (CSF) examination evidenced an infection by Mycobacterium. He was heterozygous for G20210A prothrombin mutation. Probably, hypercoagulability mechanisms of TB, added to mutation of prothrombin gene increase the risk of CVT.
ISSN:0004-282X
1678-4227
0004-282X
DOI:10.1590/s0004-282x2005000500025