Expression of nestin and vimentin in gliomatosis cerebri

Gliomatosis cerebri (GC) is a rare form of CNS neoplasia in which there is diffuse involvement of the nervous tissue with or without the presence of tumor mass. The origin of the tumor is unknown, nor whether it represents a disease with diffuse onset or infiltration from a neoplastic focus. Here we...

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Bibliographic Details
Published in:Arquivos de neuro-psiquiatria 2006-09, Vol.64 (3B), p.781-786
Main Authors: Hilbig, Arlete, Barbosa-Coutinho, Lígia Maria, Toscani, Nadima, Ribeiro, Marlise de Castro, da Cunha, Bartira Silveira Campos
Format: Article
Language:English
Subjects:
Adolescent
Adult
Astrocytoma - metabolism
Astrocytoma - pathology
Biomarkers, Tumor - analysis
Brain Neoplasms - metabolism
Brain Neoplasms - pathology
Child
Female
Glial Fibrillary Acidic Protein - analysis
Humans
Immunohistochemistry
Intermediate Filament Proteins - analysis
Magnetic Resonance Imaging
Male
Middle Aged
Nerve Tissue Proteins - analysis
Nestin
NEUROSCIENCES
PSYCHIATRY
Synaptophysin - analysis
Tomography, X-Ray Computed
Vimentin - analysis
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Summary:Gliomatosis cerebri (GC) is a rare form of CNS neoplasia in which there is diffuse involvement of the nervous tissue with or without the presence of tumor mass. The origin of the tumor is unknown, nor whether it represents a disease with diffuse onset or infiltration from a neoplastic focus. Here we studied the histopathologic characteristics of 6 cases with a diagnosis of GC and performed an immunohistochemical analysis using glial fibrillary acidic protein (GFAP), synaptophysin, nestin and vimentin. Most tumor cells were negative for GFAP, even though there were foci of positivity for this marker in all cases. We detected the presence of many positive cells for nestin and vimentin in all studied samples. The presence of these cells may indicate origin of the tumor from undifferentiated cells with a high degree of mobility.
ISSN:0004-282X
1678-4227
0004-282X
DOI:10.1590/S0004-282X2006000500015