Chronic inflammatory demyelinating polyradiculoneuropathy in chronic graft-versus-host disease following allogeneic hematopoietic stem cell transplantation: case report

The chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) is an unusual but important complication of hematopoietic stem cell transplantation (HSCT) rarely reported to date. We describe a 17-year-old woman with a diagnosis of acute myeloid leukemia due to Fanconi's anemia who was sub...

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Bibliographic Details
Published in:Arquivos de neuro-psiquiatria 2007-09, Vol.65 (3A), p.700-704
Main Authors: Lorenzoni, Paulo José, Scola, Rosana Herminia, Carsten, Ana Lucila Moreira, Trentin, Ana Paula, Teive, Hélio A G, Pasquini, Ricardo, Werneck, Lineu C
Format: Article
Language:English
Subjects:
Adolescent
Biopsy
Bone Marrow Transplantation - adverse effects
Female
Graft vs Host Disease - etiology
Graft vs Host Disease - pathology
Hematopoietic Stem Cell Transplantation - adverse effects
Humans
Leukemia, Myeloid, Acute - surgery
Motor Neurons - pathology
NEUROSCIENCES
Polyradiculoneuropathy, Chronic Inflammatory Demyelinating - etiology
Polyradiculoneuropathy, Chronic Inflammatory Demyelinating - pathology
PSYCHIATRY
Spinal Nerves - pathology
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Summary:The chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) is an unusual but important complication of hematopoietic stem cell transplantation (HSCT) rarely reported to date. We describe a 17-year-old woman with a diagnosis of acute myeloid leukemia due to Fanconi's anemia who was submitted to allogeneic HSCT and developed CIDP as part of graft-versus-host disease. Investigation showed high cerebrospinal fluid protein; electrophysiological studies revealed sensory-motor demyelinating polyradiculoneuropathy; muscle and nerve biopsy were compatible with CIDP.
ISSN:0004-282X
1678-4227
0004-282X
DOI:10.1590/S0004-282X2007000400031