Experimental nodel of C6 brain tumors in athymic rats

Malignant brain tumor experimental models tend to employ cells that are immunologically compatible with the receptor animal. In this study, we have proposed an experimental model of encephalic tumor development by injecting C6 cells into athymic Rowett rats, aiming at reaching a model which more clo...

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Bibliographic Details
Published in:Arquivos de neuro-psiquiatria 2008-06, Vol.66 (2A), p.238-241
Main Authors: Miura, Flávio K, Alves, Maria José Ferreira, Rocha, Mussya Cisotto, Silva, Roseli S, Oba-Shinjo, Sueli M, Uno, M, Colin, C, Sogayar, M C, Marie, Sueli K N
Format: Article
Language:English
Subjects:
Animals
Brain Neoplasms - pathology
Disease Models, Animal
Female
Glioma - pathology
Neoplasm Invasiveness
NEUROSCIENCES
PSYCHIATRY
Rats
Rats, Nude
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Summary:Malignant brain tumor experimental models tend to employ cells that are immunologically compatible with the receptor animal. In this study, we have proposed an experimental model of encephalic tumor development by injecting C6 cells into athymic Rowett rats, aiming at reaching a model which more closely resembles to the human glioma tumor. In our model, we observed micro-infiltration of tumor cell clusters in the vicinity of the main tumor mass, and of more distal isolated tumor cells immersed in normal encephalic parenchyma. This degree of infiltration is superior to that usually observed in other C6 models.
ISSN:0004-282X
1678-4227
0004-282X
DOI:10.1590/S0004-282X2008000200019