Proton MR spectroscopy of the foramen of Monro region in patients with tuberous sclerosis complex

• Published in: Arquivos de neuro-psiquiatria 2008-06, Vol.66 (2B), p.303-307
• Main Authors: Carvalho-Neto, Arnolfo de, Bruck, Isac, Antoniuk, Sérgio A, Marchiori, Edson, Gasparetto, Emerson L
• Format: Article
• Language: English
• Subjects: Amino Acids - metabolism; Aspartic Acid - analogs & derivatives; Aspartic Acid - analysis; Astrocytoma - diagnosis; Astrocytoma - metabolism; Basal Ganglia - metabolism; Biomarkers, Tumor - metabolism; Brain Chemistry; Case-Control Studies; Cerebral Ventricle Neoplasms - metabolism; Cerebral Ventricles - metabolism; Child; Choline - metabolism; Creatine - analysis; Early Detection of Cancer; Female; Follow-Up Studies; Humans; Magnetic Resonance Spectroscopy - methods; Male; NEUROSCIENCES; Prospective Studies; Protons; PSYCHIATRY; Tuberous Sclerosis - metabolism
• ISSN: 0004-282X; 1678-4227; 0004-282X
• DOI: 10.1590/S0004-282X2008000300003

To evaluate with 1H-magnetic resonance spectroscopy (MRS) the metabolites rations of the foramen of Monro's region in patients with tuberous sclerosis complex (TSC). Twelve patients with TSC and an age and gender-matched control group underwent MR imaging at a 1.5T scanner, and 1H-MRS at the foramen of Monro level with a multivoxel acquisition. Similar volumes of interest were selected in each side of the foramen of Monro and in the basal ganglia (lentiform nuclei). The obtained N-acetylaspartate (NAA), creatine (Cr) and choline (Cho) peak amplitude values and ratios were studied. The statistical analysis was performed and p0.05). The NAA/Cr and Cho/Cr ratios near to the foramen of Monro and basal ganglia of TSC patients are similar to the rations obtained in the control group.