Quantification of cerebrospinal fluid ferritin as a biomarker for CNS malignant infiltration

Several markers have been studied for their ability to make the CNS infiltration diagnosis earlier and more precise; previous studies showed that CSF ferritin concentrations were higher in patients with malignant invasion of CNS. The objective was to determine the importance of CSF ferritin as a bio...

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Bibliographic Details
Published in:Arquivos de neuro-psiquiatria 2008, Vol.66 (3B), p.720-724
Main Authors: Almeida, Sérgio Monteiro de, Cunha, Dione Sosnitzki da, Yamada, Edna, Doi, Elvira Missako, Ono, Margaret
Format: Article
Language:English
Subjects:
Biomarkers, Tumor - cerebrospinal fluid
Central Nervous System Neoplasms - cerebrospinal fluid
Central Nervous System Neoplasms - diagnosis
Enzyme-Linked Immunosorbent Assay
Ferritins - cerebrospinal fluid
Humans
NEUROSCIENCES
PSYCHIATRY
Sensitivity and Specificity
Taenia
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Summary:Several markers have been studied for their ability to make the CNS infiltration diagnosis earlier and more precise; previous studies showed that CSF ferritin concentrations were higher in patients with malignant invasion of CNS. The objective was to determine the importance of CSF ferritin as a biomarker for the diagnosis of CNS neoplastic infiltration. This study is based on 93 CSF samples, divided into five groups: malignant cells present (n13); malignant cells not present (n26); inflammatory neurological diseases (n16); neurocysticercosis (n20); acute bacterial meningitis (n18). CSF ferritin values were determined by micro particle enzyme immunoassay. CSF ferritin level (mean+/-SD) in the group with neoplastic cells in the CSF was 42.8+/-49.7 ng/mL, higher than in the other groups (p
ISSN:0004-282X
1678-4227
1678-4227
0004-282X
DOI:10.1590/S0004-282X2008000500022