Depression and temporal lobe epilepsy represent an epiphenomenon sharing similar neural networks: clinical and brain structural evidences

The relationship between depression and epilepsy has been known since ancient times, however, to date, it is not fully understood. The prevalence of psychiatric disorders in persons with epilepsy is high compared to general population. It is assumed that the rate of depression ranges from 20 to 55%...

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Published in:Arquivos de neuro-psiquiatria 2013-03, Vol.71 (3), p.183-190
Main Authors: Valente, Kette D R, Busatto Filho, Geraldo
Format: Article
Language:English
Subjects:
Brain - pathology
Brain - physiopathology
Depression - pathology
Depression - physiopathology
Epilepsy, Temporal Lobe - pathology
Epilepsy, Temporal Lobe - physiopathology
Humans
Nerve Net - pathology
Nerve Net - physiopathology
Neuroimaging
NEUROSCIENCES
PSYCHIATRY
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container_title Arquivos de neuro-psiquiatria
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description The relationship between depression and epilepsy has been known since ancient times, however, to date, it is not fully understood. The prevalence of psychiatric disorders in persons with epilepsy is high compared to general population. It is assumed that the rate of depression ranges from 20 to 55% in patients with refractory epilepsy, especially considering those with temporal lobe epilepsy caused by mesial temporal sclerosis. Temporal lobe epilepsy is a good biological model to understand the common structural basis between depression and epilepsy. Interestingly, mesial temporal lobe epilepsy and depression share a similar neurocircuitry involving: temporal lobes with hippocampus, amygdala and entorhinal and neocortical cortex; the frontal lobes with cingulate gyrus; subcortical structures, such as basal ganglia and thalamus; and the connecting pathways. We provide clinical and brain structural evidences that depression and epilepsy represent an epiphenomenon sharing similar neural networks.
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1678-4227
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subjects Brain - pathology
Brain - physiopathology
Depression - pathology
Depression - physiopathology
Epilepsy, Temporal Lobe - pathology
Epilepsy, Temporal Lobe - physiopathology
Humans
Nerve Net - pathology
Nerve Net - physiopathology
Neuroimaging
NEUROSCIENCES
PSYCHIATRY
title Depression and temporal lobe epilepsy represent an epiphenomenon sharing similar neural networks: clinical and brain structural evidences
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