Magnetic resonance imaging study cannot individually distinguish individuals with mild cognitive impairment, mild Alzheimer's disease, and normal aging

To evaluate the volumetric and spectroscopy aspects of hippocampus in patients with mild Alzheimer's disease (AD) and mild cognitive impairment (MCI). A series of patients older than 65 years and with memory deficit were studied. The evocation of words test presented a significant reduction in...

Full description

Saved in:
Bibliographic Details
Published in:Arquivos de neuro-psiquiatria 2013-04, Vol.71 (4), p.207-212
Main Authors: Menezes, Terce Liana, Andrade-Valença, Luciana Patrízia A, Valença, Marcelo Moraes
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Aging
Alzheimer Disease - diagnosis
Alzheimer Disease - pathology
Aspartic Acid - analogs & derivatives
Aspartic Acid - analysis
Choline - analysis
Cognitive Dysfunction - diagnosis
Cognitive Dysfunction - pathology
Diagnosis, Differential
Female
Hippocampus - chemistry
Hippocampus - pathology
Humans
Inositol - analysis
Magnetic Resonance Imaging
Male
Mental Status Schedule
NEUROSCIENCES
PSYCHIATRY
Severity of Illness Index
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:To evaluate the volumetric and spectroscopy aspects of hippocampus in patients with mild Alzheimer's disease (AD) and mild cognitive impairment (MCI). A series of patients older than 65 years and with memory deficit were studied. The evocation of words test presented a significant reduction in the number of words recalled by the patients with MCI and mild AD as compared with the control group. Bilateral reduction of the hippocampus volume in the AD group was observed when compared to the control group. There were no statistical differences in the values of NAA/Cr, mI/Cr, Cho/Cr and mI/NAA between the groups. Magnetic resonance imaging study failed to individually distinguish patients with MCI, mild AD and normal aging. However, patients with mild AD presented loss of asymmetry between the right and left hippocampus, and a reduction in hippocampus volume.
ISSN:0004-282X
1678-4227
1678-4227
0004-282X
DOI:10.1590/0004-282X20130003