Schistosoma mansoni : acquired immunity in mice after the use of oxamniquine at the evolutive skin and pulmonary phases

Mice infected with 350 cercariae of Schistosoma mansoni (LE strain) were treated with oxamniquine, at the dose of 400 mg/kg, 24, 48, 72, and 96 h after infection. Forty days after the treatment, the animals were submitted to a challenge infection with 80 cercariae, through the abdominal and ear skin...

Full description

Saved in:
Bibliographic Details
Published in:Revista do Instituto de Medicina Tropical de São Paulo 1991-01, Vol.33 (1), p.28-31
Main Authors: COELHO, P. M. Z, MELLO, B. T, GERKEN, S. E
Format: Article
Language:English
Subjects:
Administration, Oral
Animals
Antibiotics. Antiinfectious agents. Antiparasitic agents
Antiparasitic agents
Biological and medical sciences
Immunity, Active
Larva - drug effects
Lung - parasitology
Medical sciences
Mice
Oxamniquine - administration & dosage
Oxamniquine - pharmacology
Pharmacology. Drug treatments
Schistosoma mansoni - drug effects
Schistosomiasis mansoni - drug therapy
Schistosomiasis mansoni - immunology
Schistosomiasis mansoni - parasitology
Skin - parasitology
TROPICAL MEDICINE
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Mice infected with 350 cercariae of Schistosoma mansoni (LE strain) were treated with oxamniquine, at the dose of 400 mg/kg, 24, 48, 72, and 96 h after infection. Forty days after the treatment, the animals were submitted to a challenge infection with 80 cercariae, through the abdominal and ear skins. The number of immature worms in the animal groups treated 24 and 96 h after the first infection was found to be lower than that in the control group, thus showing that the death of schistosomes by chemotherapy, at the skin and pulmonary phases, causes an acquired resistance state.
ISSN:0036-4665
1678-9946
1678-9946
0036-4665
DOI:10.1590/S0036-46651991000100006