Schistosoma mansoni : preclinical studies with 9-acridanone-hydrazones in Cebus monkeys experimentally infected

Derivatives of acridine (9-Acridanone-hydrazones) were tested in Cebus monkeys experimentally infected with Schistosoma mansoni, at the dosages of 50, 25, and 12.5 mg/kg (p.o., single dose). At least, four compounds seemed to be very promising, promoting alterations in the oogram and reducing the wo...

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Bibliographic Details
Published in:Revista do Instituto de Medicina Tropical de São Paulo 1991-01, Vol.33 (1), p.50-57
Main Authors: COELHO, P. M. Z, PEREIRA, L. H
Format: Article
Language:English
Subjects:
Acridines - therapeutic use
Animals
Antibiotics. Antiinfectious agents. Antiparasitic agents
Antiparasitic agents
Biological and medical sciences
Cebus
Drug Evaluation, Preclinical
Female
Male
Medical sciences
Ovum - drug effects
Pharmacology. Drug treatments
Schistosoma mansoni - drug effects
Schistosomiasis mansoni - drug therapy
Schistosomicides - therapeutic use
TROPICAL MEDICINE
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Summary:Derivatives of acridine (9-Acridanone-hydrazones) were tested in Cebus monkeys experimentally infected with Schistosoma mansoni, at the dosages of 50, 25, and 12.5 mg/kg (p.o., single dose). At least, four compounds seemed to be very promising, promoting alterations in the oogram and reducing the worm burden drastically, even at the lowest dose (12.5 mg/kg). No side effects could be detected after drug administration.
ISSN:0036-4665
1678-9946
1678-9946
0036-4665
DOI:10.1590/S0036-46651991000100010