IDENTIFICATION OF Paracoccidioides brasiliensis IN ADRENAL GLANDS BIOPSIES OF TWO PATIENTS WITH PARACOCCIDIOIDOMYCOSIS AND ADRENAL INSUFFICIENCY

The authors report two cases of adrenal insufficiency secondary to infiltration of the adrenal glands by Paracoccidioides brasiliensis. The first patient had been treated for a chronic multifocal form of paracoccidiodomycosis 11 years ago. The diagnosis of the mycosis was done simultaneous with that...

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Published in:Revista do Instituto de Medicina Tropical de São Paulo 2009-01, Vol.51 (1), p.45-48
Main Authors: AGUDELO, Carlos Andrés, MUNOZ, Carolina, RAMIREZ, Alex, GUTIERREZ, Jonhairo, VELEZ, Santiago, CAMILO PEREZ, Juan, VELEZ, Alejandro, TOBON, Angela Maria, RESTREPO, Angela
Format: Article
Language:English
Subjects:
Adrenal Glands - microbiology
Adrenal Insufficiency - diagnosis
Adrenal Insufficiency - drug therapy
Adrenal Insufficiency - microbiology
Adrenals. Adrenal axis. Renin-angiotensin system (diseases)
Anti-Inflammatory Agents - therapeutic use
Antifungal Agents - therapeutic use
Biological and medical sciences
Biopsy
Blastomycoses and paracoccidioidomycosis
Endocrinopathies
Fludrocortisone - therapeutic use
General aspects
Human mycoses
Humans
Infectious diseases
Itraconazole - therapeutic use
Male
Medical sciences
Middle Aged
Mycoses
Non tumoral diseases. Target tissue resistance. Benign neoplasms
Paracoccidioides - isolation & purification
Paracoccidioidomycosis - diagnosis
Paracoccidioidomycosis - drug therapy
Prednisone - therapeutic use
Tomography, X-Ray Computed
TROPICAL MEDICINE
Tropical mycoses
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Summary:The authors report two cases of adrenal insufficiency secondary to infiltration of the adrenal glands by Paracoccidioides brasiliensis. The first patient had been treated for a chronic multifocal form of paracoccidiodomycosis 11 years ago. The diagnosis of the mycosis was done simultaneous with that of the adrenal insufficiency in the second patient. In both patients the diagnosis was done by direct visualization of fungus in adrenal biopsies. They were treated with hormonal supplements and itraconazol by 12 and six months, without relapses during the follow-up period.
ISSN:0036-4665
1678-9946
1678-9946
0036-4665
DOI:10.1590/S0036-46652009000100008