Experimental lagochilascariosis in X-chromosome-linked immunodeficient mice

Lagochilascaris minor is the etiological agent of lagochilascariosis, a disease that affects the neck region and causes exudative abscesses, with eggs, adult parasites and L3/L4 larvae in the purulent exudates. Mice are now considered to be intermediate hosts for the parasite. To determine the patte...

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Bibliographic Details
Published in:Revista da Sociedade Brasileira de Medicina Tropical 2009-07, Vol.42 (4), p.381-385
Main Authors: de Freitas, Jaqueline Aparecida Gleice, Prudente, Mariana Félix de Souza, Carvalhaes, Mara Silvia
Format: Article
Language:English
Subjects:
Animals
Antibodies, Helminth - immunology
Antigens, Helminth - immunology
Ascaridida Infections - immunology
Ascaridida Infections - parasitology
Ascaridoidea - immunology
Enzyme-Linked Immunosorbent Assay
Host-Parasite Interactions - immunology
Immunoglobulin Isotypes - biosynthesis
Immunoglobulin Isotypes - blood
Larvae
Male
Mice
Mice, Inbred BALB C
Mice, Inbred mdx
Parasites
Time Factors
TROPICAL MEDICINE
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Summary:Lagochilascaris minor is the etiological agent of lagochilascariosis, a disease that affects the neck region and causes exudative abscesses, with eggs, adult parasites and L3/L4 larvae in the purulent exudates. Mice are now considered to be intermediate hosts for the parasite. To determine the pattern of infection in B1 cell-deficient mice, experimental lagochilascariosis was studied in BALB/c and X-chromosome-linked immunodeficient (xid) mice. BALB.xid-infected mice showed lower numbers of larvae. Third-stage larvae, fourth-stage larvae and adult parasites were found in both strains. BALB/c mice produced IgM, IgG, IgA and IgE against the crude extract and secreted/excreted antigens of the parasite. On the other hand, BALB.xid mice did not produce IgM and produced lower levels of IgG and IgA, and similar quantities of IgE.
ISSN:0037-8682
1678-9849
1678-9849
0037-8682
DOI:10.1590/S0037-86822009000400005