Family Herpesviridae and neuroinfections: current status and research in progress

This article addresses the relationship between human herpesviruses (HHVs) and neuroinfections. Alphaherpesviruses, betaherpesviruses and gammaherpesviruses are neurotropic viruses that establish latency and exhibit reactivation capacity. Encephalitis and meningitis are common in cases of HHV. The c...

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Bibliographic Details
Published in:Memórias do Instituto Oswaldo Cruz 2022-01, Vol.117, p.e220200-e220200
Main Authors: Carneiro, Vanessa Cristine de Souza, Pereira, Jéssica Gonçalves, de Paula, Vanessa Salete
Format: Article
Language:English
Subjects:
Epstein-Barr Virus Infections
Herpesviridae
Herpesviridae Infections - pathology
Herpesvirus 1, Human
Herpesvirus 4, Human
Humans
PARASITOLOGY
TROPICAL MEDICINE
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Summary:This article addresses the relationship between human herpesviruses (HHVs) and neuroinfections. Alphaherpesviruses, betaherpesviruses and gammaherpesviruses are neurotropic viruses that establish latency and exhibit reactivation capacity. Encephalitis and meningitis are common in cases of HHV. The condition promoted by HHV infection is a purported trigger for certain neurodegenerative diseases. Ongoing studies have identified an association between HSV-1 and the occurrence of Alzheimer's disease, multiple sclerosis and infections by HHV-6 and Epstein-Barr virus. In this review, we highlight the importance of research investigating the role of herpesviruses in the pathogenesis of diseases that affect the nervous system and describe other studies in progress.
ISSN:0074-0276
1678-8060
1678-8060
DOI:10.1590/0074-02760220200