Early trends and predictors of renal function following computed tomography-guided percutaneous cryoablation of a renal mass in patients with and without prior renal impairment

• Published in: Radiologia brasileira 2020-05, Vol.53 (3), p.141-147
• Main Authors: Staziaki, Pedro V, Vadvala, Harshna V, Furtado, Vanessa Fiorini, Daye, Dania, Arellano, Ronald S, Uppot, Raul N
• Format: Article
• Language: English
• Subjects: Original; RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
• ISSN: 0100-3984; 1678-7099; 1678-7099
• DOI: 10.1590/0100-3984.2019.0098

To assess trends and predictors of the glomerular filtration rate (GFR) after renal mass cryoablation in patients with and without history of renal impairment. This was a retrospective study of 39 patients who underwent computed tomography-guided percutaneous cryoablation of a renal mass, divided into two groups: those with prior renal impairment (PRI+); and those without prior renal impairment (PRI-). The GFR trend and the chronic kidney disease stage were evaluated at baseline, as well as at 1, 6, and 12 months after cryoablation. Predictors of GFR at 1 and 6 months were modeled with linear regression. In both groups, the mean GFR at 1 month and 6 months was significantly lower than at baseline ( < 0.001 and = 0.01, respectively). Although the GFR was lower across all time points in the PRI+ group (-26.1; < 0.001), the overall trend was not statistically different from that observed in the PRI- group ( = 0.89). Univariate analysis showed that the decline in GFR at 1 and 6 months correlated with the baseline GFR (0.77 and 0.63; < 0.001 and = 0.03, respectively) and with the size of the ablation zone (-7.6 and -12.84, respectively; = 0.03 for both). However, in the multivariate model, baseline GFR was predictive only of GFR at 1 month ( < 0.001). The trend in GFR decline after cryoablation is similar for patients with and without a history of renal impairment. Baseline GFR predicts the mean GFR in the early post-cryoablation period.