Measuring exposure of organochlorinated pesticides

Environmental epidemiological investigations in cancer remain, with rare exceptions, inconclusive. The difficulties of establishing patterns of measurements of exposure in the human body is one of the limitations of these studies. The findings of six recent epidemiological studies that analyzed the...

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Bibliographic Details
Published in:Cadernos de saúde pública 1998, Vol.14 Suppl 3 (suppl 3), p.177-S179
Main Author: Azevedo e Silva Mendonça, G
Format: Article
Language:English
Subjects:
Adipose Tissue - chemistry
Animals
Breast Neoplasms - chemically induced
Carcinogens, Environmental - adverse effects
Carcinogens, Environmental - analysis
Environmental Exposure - adverse effects
Environmental Exposure - analysis
Female
Humans
Hydrocarbons, Chlorinated
Insecticides - adverse effects
Insecticides - analysis
Male
Mammary Neoplasms, Animal - chemically induced
PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH
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Summary:Environmental epidemiological investigations in cancer remain, with rare exceptions, inconclusive. The difficulties of establishing patterns of measurements of exposure in the human body is one of the limitations of these studies. The findings of six recent epidemiological studies that analyzed the association between organochlorinated compounds and breast cancer are reviewed in considering the problems of measuring environmental exposure through biological markers. The epidemiological evidence based on these studies do not indicate a risk of breast cancer related to organochlorines. Some aspects that may partially explain this absence of risk are discussed regarding the investigation of environmental carcinogenic agents in populations with low but homogeneously sprayed levels of exposure.
ISSN:0102-311X
1678-4464
0102-311X
DOI:10.1590/S0102-311X1998000700018