Impact of the Haemophilus influenzae type b vaccination program on HIB meningitis in Brazil

This study aimed to evaluate the impact of vaccination against Haemophilus influenzae type b (HIB) in Brazil on the morbidity, mortality, and case fatality of HIB meningitis, using the Ministry of Health database and population data from the Brazilian Institute of Geography and Statistics (Instituto...

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Bibliographic Details
Published in:Cadernos de saúde pública 2007-07, Vol.23 (7), p.1689-1695
Main Authors: Miranzi, Sybelle de Souza Castro, de Moraes, Suzana Alves, de Freitas, Isabel Cristina Martins
Format: Article
Language:English
Subjects:
Brazil - epidemiology
Child, Preschool
Clinical Laboratory Information Systems
Forecasting
Haemophilus influenzae type b - immunology
Haemophilus Vaccines - administration & dosage
Humans
Immunization Programs
Incidence
Infant
Infant, Newborn
Meningitis, Haemophilus - epidemiology
Meningitis, Haemophilus - mortality
Meningitis, Haemophilus - prevention & control
PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH
Regression Analysis
Survival Analysis
Vaccination - standards
Vaccines, Conjugate
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Summary:This study aimed to evaluate the impact of vaccination against Haemophilus influenzae type b (HIB) in Brazil on the morbidity, mortality, and case fatality of HIB meningitis, using the Ministry of Health database and population data from the Brazilian Institute of Geography and Statistics (Instituto Brasileiro de Geografia e Estatística--IBGE). Impact was evaluated through a time series analysis (1983-2002), using regression forecasting (RF) by dividing the time series into two periods: (a) historical (1983-1998) and (b) validation (1999-2002). Impact of the vaccination was positive, although more significant for incidence and mortality than for case fatality rates.
ISSN:0102-311X
1678-4464
0102-311X
DOI:10.1590/S0102-311X2007000700021