Diffuse alveolar hemorrhage resulting from Pauci-immune pulmonary capillaritis

A 27 year-old female patient, cocaine user, presenting hemoptysis and progressive dyspnea with onset 48 hours prior to hospital admission, without any other signs or symptoms. Serum tests for infectious diseases, collagen disorders and vasculitis were negative. Urinalysis was normal. Computed tomogr...

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Bibliographic Details
Published in:Jornal de Pneumologia 2003-08, Vol.29 (4), p.217-220
Main Authors: Monteiro, Andreia Salarini, Addor, Gabriela, Nigri, David Henrique, Torres, Wilhermo, Franco, Carlos Alberto de Barros
Format: Article
Language:English
Subjects:
RESPIRATORY SYSTEM
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Summary:A 27 year-old female patient, cocaine user, presenting hemoptysis and progressive dyspnea with onset 48 hours prior to hospital admission, without any other signs or symptoms. Serum tests for infectious diseases, collagen disorders and vasculitis were negative. Urinalysis was normal. Computed tomography of the chest showed diffuse alveolar infiltrate, affecting mainly the lower left lobe. A thoracoscopic lung biopsy was performed to clarify the diagnosis. The histopathological findings showed capillaritis and diffuse intra-alveolar hemorrhage. Treated with steroid and cyclophosphamide pulse therapy, a good clinical and radiographical response was obtained. The recently described pauci-immune pulmonary capillaritis is characterized by the presence of isolated pulmonary capillaritis and negative serum testing for auto-immune diseases.
ISSN:0102-3586
1678-4642
0102-3586
DOI:10.1590/S0102-35862003000400010