Electrical Stimulation Prevents Muscular Atrophy and the Decrease of Interleukin-6 in Paralyzed Muscles after Spinal Cord Injury in Rats

To analyze the muscle trophism and expression of interleukin-6 in the biceps brachii muscle of rats with incomplete cervical spinal cord injury treated with neuromuscular electrical stimulation (NMES).  Adult rats underwent C5-C7 spinal cord hemisection and a 5-week NMES protocol. Trophism of the bi...

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Published in:Revista brasileira de ortopedia 2024-08, Vol.59 (4), p.e526-e531
Main Authors: Machado-Pereira, Nicolas A M M, do Nascimento, Patrícia S, de Freitas, Gabriel R, Bobinski, Franciane, do Espírito Santo, Caroline C, Ilha, Jocemar
Format: Article
Language:English
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ORTHOPEDICS
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Summary:To analyze the muscle trophism and expression of interleukin-6 in the biceps brachii muscle of rats with incomplete cervical spinal cord injury treated with neuromuscular electrical stimulation (NMES).  Adult rats underwent C5-C7 spinal cord hemisection and a 5-week NMES protocol. Trophism of the biceps brachii was assessed using muscle weight/body weight ratio and histological analysis. Interleukin-6 expression from biceps brachii was measured using the enzyme-linked immunosorbent assay technique.  Preservation of the biceps brachii muscle trophism was found in the NMES treated group, along with prevention of the reduction of interleukin-6 levels.  Spinal cord injury causes muscle atrophy and decreases interleukin-6 levels. These alterations are partially prevented by NMES. The results suggest a possible NMES action mechanism and underscore the clinical use of this therapeutic tool.
ISSN:0102-3616
1982-4378
1982-4378
DOI:10.1055/s-0044-1787767