Antinociceptive effects of Abarema cochliacarpos (B.A. Gomes) Barneby & J.W.Grimes (Mimosaceae)

In this study, we investigated the analgesic activity of crude aqueous and methanol extracts obtained from Abarema cochliacarpos bark in mice, and analyzed its phytochemical profile. All the extracts exhibited analgesic properties against the writhing test in mice, but the aqueous and methanol extra...

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Bibliographic Details
Published in:Revista brasileira de farmacognosia 2009-03, Vol.19 (1a), p.46-50
Main Authors: Silva, Nina C. B., Esquibel, Maria A., Alves, Iura M., Velozo, Eudes S., Almeida, Mara Z., Santos, Jaci E. S., Campos-Buzzi, Fátima de, Meira, Aleandra V., Cechinel-Filho, Valdir
Format: Article
Language:English
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PHARMACOLOGY & PHARMACY
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Summary:In this study, we investigated the analgesic activity of crude aqueous and methanol extracts obtained from Abarema cochliacarpos bark in mice, and analyzed its phytochemical profile. All the extracts exhibited analgesic properties against the writhing test in mice, but the aqueous and methanol extracts were more active, and more potent than two known analgesic and anti-inflammatory drugs used as reference. They were also active against the capsaicin-model, but inactive when evaluated in the hot-plate test. Phytochemical studies revealed the presence of saponins, catechins, tannins, phenols and anthraquinones.
ISSN:0102-695X
1981-528X
DOI:10.1590/S0102-695X2009000100011