Constituents and antiproliferative activity of extracts from leaves of Croton macrobothrys

Croton macrobothrys Baill, Euphorbiaceae, is a tree from the Atlantic Forest in Southern Brazil, used in traditional medicine and popularly known as "dragon's blood" and "pau-sangue". Leaf n-hexane, dichloromethane and methanol extracts were analyzed by GC/MS and evaluated f...

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Published in:Revista brasileira de farmacognosia 2011-12, Vol.21 (6), p.972-977
Main Authors: Motta, Lucimar B., Furlan, Cláudia M., Santos, Deborah Y. A. C., Salatino, Maria L. F., Duarte-Almeida, Joaquim M., Negri, Giuseppina, Carvalho, João E. de, Ruiz, Ana Lúcia T. G., Cordeiro, Inês, Salatino, Antonio
Format: Article
Language:English
Subjects:
PHARMACOLOGY & PHARMACY
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Summary:Croton macrobothrys Baill, Euphorbiaceae, is a tree from the Atlantic Forest in Southern Brazil, used in traditional medicine and popularly known as "dragon's blood" and "pau-sangue". Leaf n-hexane, dichloromethane and methanol extracts were analyzed by GC/MS and evaluated for their in vitro antiproliferative activity on cell lines 786-0 (kidney), HT-29 (colon), K562 (leukemia), NCI-ADR/RES (drug resistant ovary), NCI-H460 (lung), MCF-7 (mammary), PC-3 (prostate), OVCAR-3 (ovary), U251 (glioma) and UACC-62 (melanoma). The dicloromethane extract exhibited activity against all cell lines at the concentration 25 µg/mL, in particular on cell lines NCI-H460 (GI50 0.33 μg/mL) and K5662 (GI50 0.91 μg/mL). Relevant constituents in dichloromethane extract are the alkaloids corydine and salutaridine, as well as the diterpenes geranylgeraniol and crotonin-derived clerodanes.
ISSN:0102-695X
1981-528X
DOI:10.1590/S0102-695X2011005000174