Protective role of Ficus benghalensis against isoniazid-rifampicin induced oxidative liver injury in rat

The present study was made to investigate the protective effect of methanolic extract of Ficus benghalensis L., Moraceae, on isoniazid-rifampicin-induced hepatotoxicity in rats. Rats were divided into six different groups; group 1 served as a control, group 2 received isoniazid and rifampicin (100 m...

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Bibliographic Details
Published in:Revista brasileira de farmacognosia 2012-06, Vol.22 (3), p.604-610
Main Authors: Parameswari, S. Angala, Saleem, T. S. Mohamed, Chandrasekar, K. B, Chetty, C. Madhusudhana
Format: Article
Language:English
Subjects:
PHARMACOLOGY & PHARMACY
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Summary:The present study was made to investigate the protective effect of methanolic extract of Ficus benghalensis L., Moraceae, on isoniazid-rifampicin-induced hepatotoxicity in rats. Rats were divided into six different groups; group 1 served as a control, group 2 received isoniazid and rifampicin (100 mg/kg, i.p.), in sterile water, groups 3, 4 and 5 received 100, 200 & 300 mg/kg bw, p.o. methanolic extract of F. benghalensis and group 6 received Liv 52. All the treatment protocols followed 21 days and after rats were sacrificed blood and liver were used for biochemical and histological studies, respectively. Administration of isoniazid and rifampicin caused a significant elevation in the levels of liver marker enzymes (p
ISSN:0102-695X
1981-528X
DOI:10.1590/S0102-695X2012005000009