Loading…

Toxicological evaluation of ethanolic extract of Lychnophora trichocarpha, Brazilian arnica

The species of the genus Lychnophora, Asteraceae, are popularly known as "arnica" and are native from Brazilian savana (Cerrado). They are widely used in Brazilian folk medicine as anti-inflammatory, to treat bruise, pain, rheumatism and for insect bites. For evaluation of acute toxicity,...

Full description

Saved in:
Bibliographic Details
Published in:Revista brasileira de farmacognosia 2012-10, Vol.22 (5), p.1104-1110
Main Authors: Ferrari, Fernanda C., Grabe-Guimarães, Andrea, Carneiro, Cláudia M., Souza, Maíra R. de, Ferreira, Leidiane C., Oliveira, Tânia T. de, Saúde-Guimarães, Dênia A.
Format: Article
Language:English
Subjects:
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c345t-ad5c15cdc52db4e99af9febf0f1076ced157b7a02b5645a69514bdc50b642a633
cites
container_end_page 1110
container_issue 5
container_start_page 1104
container_title Revista brasileira de farmacognosia
container_volume 22
creator Ferrari, Fernanda C.
Grabe-Guimarães, Andrea
Carneiro, Cláudia M.
Souza, Maíra R. de
Ferreira, Leidiane C.
Oliveira, Tânia T. de
Saúde-Guimarães, Dênia A.
description The species of the genus Lychnophora, Asteraceae, are popularly known as "arnica" and are native from Brazilian savana (Cerrado). They are widely used in Brazilian folk medicine as anti-inflammatory, to treat bruise, pain, rheumatism and for insect bites. For evaluation of acute toxicity, the ethanolic extract was given to albino female and male mice. In open-field test, the extract of Lychnophora trichocarpha (Spreng.) Spreng. (0.750 g/kg) induced a significant inhibition of the spontaneous locomotor activity and exploratory behavior of the animals were observed 1 and 4 h after administration. In traction test, the same dose reduced the muscular force 1 h after administration. The exploratory behavior reduced significantly in the group that received 0.50 g/kg, 1 and 4 h after administration of the extract. The animals that received the doses of 0.25, 0.50 and 0.75 g/kg did not show any change of blood biochemical parameters comparing to control group and showed some histopathological changes such as congestion and inflammation of kidney and liver. The dose of 1.5 g/kg caused the most serious signs of toxicity. Histopathological changes observed was hemorrhage in 62.5% and pulmonary congestion in 100% of the animals. Brain and liver congestion was found in 62.5% of the animals.
doi_str_mv 10.1590/S0102-695X2012005000089
format article
fullrecord <record><control><sourceid>scielo_cross</sourceid><recordid>TN_cdi_scielo_journals_S0102_695X2012000500023</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><scielo_id>S0102_695X2012000500023</scielo_id><sourcerecordid>S0102_695X2012000500023</sourcerecordid><originalsourceid>FETCH-LOGICAL-c345t-ad5c15cdc52db4e99af9febf0f1076ced157b7a02b5645a69514bdc50b642a633</originalsourceid><addsrcrecordid>eNplkMFOwzAMhnMAiTF4BvIAdDhp065HmIAhTeLAkJA4VK6b0EyhmdIObTw97TbBAV8s-ff_W_4YuxIwESqHmxcQIKM0V28ShARQ0Nc0P2GjX-GMnbftqpfSqZyO2PvSby155z8soeP6C90GO-sb7g3XXY2Nd5a43nYBqRuGix3VjV_XPiDvgqXaE4Z1jdf8LuC3dRYbjqHp4y7YqUHX6stjH7PXh_vlbB4tnh-fZreLiOJEdRFWioSiipSsykTnOZrc6NKAEZClpCuhsjJDkKVKE4X9EyIp-20o00RiGsdjNjnktmS188XKb0LTHyz2OIo_HHsecjBkBwMF37ZBm2Id7CeGXSGgGED-cx5Bxj8zr2h8</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Toxicological evaluation of ethanolic extract of Lychnophora trichocarpha, Brazilian arnica</title><source>SciELO</source><creator>Ferrari, Fernanda C. ; Grabe-Guimarães, Andrea ; Carneiro, Cláudia M. ; Souza, Maíra R. de ; Ferreira, Leidiane C. ; Oliveira, Tânia T. de ; Saúde-Guimarães, Dênia A.</creator><creatorcontrib>Ferrari, Fernanda C. ; Grabe-Guimarães, Andrea ; Carneiro, Cláudia M. ; Souza, Maíra R. de ; Ferreira, Leidiane C. ; Oliveira, Tânia T. de ; Saúde-Guimarães, Dênia A.</creatorcontrib><description>The species of the genus Lychnophora, Asteraceae, are popularly known as "arnica" and are native from Brazilian savana (Cerrado). They are widely used in Brazilian folk medicine as anti-inflammatory, to treat bruise, pain, rheumatism and for insect bites. For evaluation of acute toxicity, the ethanolic extract was given to albino female and male mice. In open-field test, the extract of Lychnophora trichocarpha (Spreng.) Spreng. (0.750 g/kg) induced a significant inhibition of the spontaneous locomotor activity and exploratory behavior of the animals were observed 1 and 4 h after administration. In traction test, the same dose reduced the muscular force 1 h after administration. The exploratory behavior reduced significantly in the group that received 0.50 g/kg, 1 and 4 h after administration of the extract. The animals that received the doses of 0.25, 0.50 and 0.75 g/kg did not show any change of blood biochemical parameters comparing to control group and showed some histopathological changes such as congestion and inflammation of kidney and liver. The dose of 1.5 g/kg caused the most serious signs of toxicity. Histopathological changes observed was hemorrhage in 62.5% and pulmonary congestion in 100% of the animals. Brain and liver congestion was found in 62.5% of the animals.</description><identifier>ISSN: 0102-695X</identifier><identifier>ISSN: 1981-528X</identifier><identifier>DOI: 10.1590/S0102-695X2012005000089</identifier><language>eng</language><publisher>Sociedade Brasileira de Farmacognosia</publisher><subject>PHARMACOLOGY &amp; PHARMACY</subject><ispartof>Revista brasileira de farmacognosia, 2012-10, Vol.22 (5), p.1104-1110</ispartof><rights>This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c345t-ad5c15cdc52db4e99af9febf0f1076ced157b7a02b5645a69514bdc50b642a633</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,24150,27924,27925</link.rule.ids></links><search><creatorcontrib>Ferrari, Fernanda C.</creatorcontrib><creatorcontrib>Grabe-Guimarães, Andrea</creatorcontrib><creatorcontrib>Carneiro, Cláudia M.</creatorcontrib><creatorcontrib>Souza, Maíra R. de</creatorcontrib><creatorcontrib>Ferreira, Leidiane C.</creatorcontrib><creatorcontrib>Oliveira, Tânia T. de</creatorcontrib><creatorcontrib>Saúde-Guimarães, Dênia A.</creatorcontrib><title>Toxicological evaluation of ethanolic extract of Lychnophora trichocarpha, Brazilian arnica</title><title>Revista brasileira de farmacognosia</title><addtitle>Rev. bras. farmacogn</addtitle><description>The species of the genus Lychnophora, Asteraceae, are popularly known as "arnica" and are native from Brazilian savana (Cerrado). They are widely used in Brazilian folk medicine as anti-inflammatory, to treat bruise, pain, rheumatism and for insect bites. For evaluation of acute toxicity, the ethanolic extract was given to albino female and male mice. In open-field test, the extract of Lychnophora trichocarpha (Spreng.) Spreng. (0.750 g/kg) induced a significant inhibition of the spontaneous locomotor activity and exploratory behavior of the animals were observed 1 and 4 h after administration. In traction test, the same dose reduced the muscular force 1 h after administration. The exploratory behavior reduced significantly in the group that received 0.50 g/kg, 1 and 4 h after administration of the extract. The animals that received the doses of 0.25, 0.50 and 0.75 g/kg did not show any change of blood biochemical parameters comparing to control group and showed some histopathological changes such as congestion and inflammation of kidney and liver. The dose of 1.5 g/kg caused the most serious signs of toxicity. Histopathological changes observed was hemorrhage in 62.5% and pulmonary congestion in 100% of the animals. Brain and liver congestion was found in 62.5% of the animals.</description><subject>PHARMACOLOGY &amp; PHARMACY</subject><issn>0102-695X</issn><issn>1981-528X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><recordid>eNplkMFOwzAMhnMAiTF4BvIAdDhp065HmIAhTeLAkJA4VK6b0EyhmdIObTw97TbBAV8s-ff_W_4YuxIwESqHmxcQIKM0V28ShARQ0Nc0P2GjX-GMnbftqpfSqZyO2PvSby155z8soeP6C90GO-sb7g3XXY2Nd5a43nYBqRuGix3VjV_XPiDvgqXaE4Z1jdf8LuC3dRYbjqHp4y7YqUHX6stjH7PXh_vlbB4tnh-fZreLiOJEdRFWioSiipSsykTnOZrc6NKAEZClpCuhsjJDkKVKE4X9EyIp-20o00RiGsdjNjnktmS188XKb0LTHyz2OIo_HHsecjBkBwMF37ZBm2Id7CeGXSGgGED-cx5Bxj8zr2h8</recordid><startdate>20121001</startdate><enddate>20121001</enddate><creator>Ferrari, Fernanda C.</creator><creator>Grabe-Guimarães, Andrea</creator><creator>Carneiro, Cláudia M.</creator><creator>Souza, Maíra R. de</creator><creator>Ferreira, Leidiane C.</creator><creator>Oliveira, Tânia T. de</creator><creator>Saúde-Guimarães, Dênia A.</creator><general>Sociedade Brasileira de Farmacognosia</general><scope>AAYXX</scope><scope>CITATION</scope><scope>GPN</scope></search><sort><creationdate>20121001</creationdate><title>Toxicological evaluation of ethanolic extract of Lychnophora trichocarpha, Brazilian arnica</title><author>Ferrari, Fernanda C. ; Grabe-Guimarães, Andrea ; Carneiro, Cláudia M. ; Souza, Maíra R. de ; Ferreira, Leidiane C. ; Oliveira, Tânia T. de ; Saúde-Guimarães, Dênia A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c345t-ad5c15cdc52db4e99af9febf0f1076ced157b7a02b5645a69514bdc50b642a633</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>PHARMACOLOGY &amp; PHARMACY</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ferrari, Fernanda C.</creatorcontrib><creatorcontrib>Grabe-Guimarães, Andrea</creatorcontrib><creatorcontrib>Carneiro, Cláudia M.</creatorcontrib><creatorcontrib>Souza, Maíra R. de</creatorcontrib><creatorcontrib>Ferreira, Leidiane C.</creatorcontrib><creatorcontrib>Oliveira, Tânia T. de</creatorcontrib><creatorcontrib>Saúde-Guimarães, Dênia A.</creatorcontrib><collection>CrossRef</collection><collection>SciELO</collection><jtitle>Revista brasileira de farmacognosia</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ferrari, Fernanda C.</au><au>Grabe-Guimarães, Andrea</au><au>Carneiro, Cláudia M.</au><au>Souza, Maíra R. de</au><au>Ferreira, Leidiane C.</au><au>Oliveira, Tânia T. de</au><au>Saúde-Guimarães, Dênia A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Toxicological evaluation of ethanolic extract of Lychnophora trichocarpha, Brazilian arnica</atitle><jtitle>Revista brasileira de farmacognosia</jtitle><addtitle>Rev. bras. farmacogn</addtitle><date>2012-10-01</date><risdate>2012</risdate><volume>22</volume><issue>5</issue><spage>1104</spage><epage>1110</epage><pages>1104-1110</pages><issn>0102-695X</issn><issn>1981-528X</issn><abstract>The species of the genus Lychnophora, Asteraceae, are popularly known as "arnica" and are native from Brazilian savana (Cerrado). They are widely used in Brazilian folk medicine as anti-inflammatory, to treat bruise, pain, rheumatism and for insect bites. For evaluation of acute toxicity, the ethanolic extract was given to albino female and male mice. In open-field test, the extract of Lychnophora trichocarpha (Spreng.) Spreng. (0.750 g/kg) induced a significant inhibition of the spontaneous locomotor activity and exploratory behavior of the animals were observed 1 and 4 h after administration. In traction test, the same dose reduced the muscular force 1 h after administration. The exploratory behavior reduced significantly in the group that received 0.50 g/kg, 1 and 4 h after administration of the extract. The animals that received the doses of 0.25, 0.50 and 0.75 g/kg did not show any change of blood biochemical parameters comparing to control group and showed some histopathological changes such as congestion and inflammation of kidney and liver. The dose of 1.5 g/kg caused the most serious signs of toxicity. Histopathological changes observed was hemorrhage in 62.5% and pulmonary congestion in 100% of the animals. Brain and liver congestion was found in 62.5% of the animals.</abstract><pub>Sociedade Brasileira de Farmacognosia</pub><doi>10.1590/S0102-695X2012005000089</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 0102-695X
ispartof Revista brasileira de farmacognosia, 2012-10, Vol.22 (5), p.1104-1110
issn 0102-695X
1981-528X
language eng
recordid cdi_scielo_journals_S0102_695X2012000500023
source SciELO
subjects PHARMACOLOGY & PHARMACY
title Toxicological evaluation of ethanolic extract of Lychnophora trichocarpha, Brazilian arnica
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-07T10%3A49%3A51IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-scielo_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Toxicological%20evaluation%20of%20ethanolic%20extract%20of%20Lychnophora%20trichocarpha,%20Brazilian%20arnica&rft.jtitle=Revista%20brasileira%20de%20farmacognosia&rft.au=Ferrari,%20Fernanda%20C.&rft.date=2012-10-01&rft.volume=22&rft.issue=5&rft.spage=1104&rft.epage=1110&rft.pages=1104-1110&rft.issn=0102-695X&rft_id=info:doi/10.1590/S0102-695X2012005000089&rft_dat=%3Cscielo_cross%3ES0102_695X2012000500023%3C/scielo_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c345t-ad5c15cdc52db4e99af9febf0f1076ced157b7a02b5645a69514bdc50b642a633%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_id=info:pmid/&rft_scielo_id=S0102_695X2012000500023&rfr_iscdi=true