Two new diterpenoids from Leonurus japonicus

Two new labdane-type diterpenoids were isolated from the EtOH extract of the herb of Leonurus japonicus. Their chemical structures were determined by the analysis of 1D, 2D NMR, and HRESIMS, and by comparing with known analogs. Two new labdane-type diterpenoids, 5-ethoxy-3-(2-((R)-4-hydroxy-2,5,5,8a...

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Published in:Revista brasileira de farmacognosia 2015-03, Vol.25 (2), p.180-182
Main Authors: Wu, Hankui, Wang, Sensheng, Liu, Haijuan, E, Yan, Li, Yan, Liu, Ruijin, Wang, Jinjin, Xu, Zhiyong, Lv, Yanyan, Sun, Shanshan, Li, Gang, Shi, Yunfeng
Format: Article
Language:English
Subjects:
Labdane diterpenoid
Leonurus japonicus
PHARMACOLOGY & PHARMACY
Pharmacy
Short Communication
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Summary:Two new labdane-type diterpenoids were isolated from the EtOH extract of the herb of Leonurus japonicus. Their chemical structures were determined by the analysis of 1D, 2D NMR, and HRESIMS, and by comparing with known analogs. Two new labdane-type diterpenoids, 5-ethoxy-3-(2-((R)-4-hydroxy-2,5,5,8a-tetramethyl-3-oxo-3,5,6,7,8,8a-hexahydronaphthalen-1-yl)ethyl)furan-2(5H)-one (1), and 5-hydroxy-4-(2-((1R,3S,7aS)-1-hydroxy-4,4,7a-trimethyl-3-propionyloctahydroisobenzofuran-1-yl)ethyl)furan-2(5H)-one (2), were isolated from the EtOH extract of the herb of Leonurus japonicus Houtt., Lamiaceae. Their chemical structures were determined by analysis of 1D, 2D NMR, HRESIMS, and by comparison with known analogs.
ISSN:0102-695X
1981-528X
1981-528X
DOI:10.1016/j.bjp.2015.02.006