Physicochemical, biological and release studies of chitosan membranes incorporated with Euphorbia umbellata fraction

[Display omitted] Formulations containing chitosan incorporated with methanolic fraction of Euphorbia umbellata (Pax) Bruyns, Euphorbiaceae, were studied aiming future applications of this new material as medicine. In order to investigate potential interactions between chitosan and the methanolic fr...

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Bibliographic Details
Published in:Revista brasileira de farmacognosia 2018-07, Vol.28 (4), p.433-443
Main Authors: Lemes, Bruna M., Novatski, Andressa, Ferrari, Priscileila C., Minozzo, Bruno R., Justo, Aline da S., Petry, Victor E.K., Vellosa, José C.R., Sabino, Simone do R.F., Gunha, Jaqueline V., Esmerino, Luís A., Beltrame, Flávio L.
Format: Article
Language:English
Subjects:
Bark methanolic fraction
Chemical interactions
Medicine
Original Article
PHARMACOLOGY & PHARMACY
Pharmacy
Phenolic compounds
Physicochemical characterization
Release profile
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Summary:[Display omitted] Formulations containing chitosan incorporated with methanolic fraction of Euphorbia umbellata (Pax) Bruyns, Euphorbiaceae, were studied aiming future applications of this new material as medicine. In order to investigate potential interactions between chitosan and the methanolic fraction (10, 50 and 100% in relation to the amount of chitosan) physicochemical characterization was performed by scanning electron microscopy, density, differential scanning calorimetry, thermogravimetry, X-ray diffraction, Fourier-transform infrared spectroscopy and colorimetry techniques. The phenolic compounds released from the chitosan membranes were evaluated using the Folin-Ciocalteau quantification method; antioxidant and antimicrobial activity were also studied. Increasing amounts of the methanolic fraction added to polymeric matrix produced different numbers of pores on the surface of the membranes, changes in the calorimetric, spectroscopic and crystalline properties as well as color changes, when compared to the inert membrane. These changes can be attributed to chemical interactions that occurred between the structure of the chitosan and the phenolic compounds present in the studied fraction. The matrix samples incorporated with 50 and 100% of the methanolic fraction presented different release profiles of phenolic compounds from the membranes (controlled manner) and promoted antioxidant and antimicrobial activity.
ISSN:0102-695X
1981-528X
1981-528X
DOI:10.1016/j.bjp.2018.05.001