m 6A RNA Methylation Decreases Atherosclerotic Vulnerable Plaque Through Inducing T Cells

ABSTRACT Introduction: Knockdown of fat mass and obesity-associated gene (FTO) can induce N6-methyladenosine (m 6A) ribonucleic acid (RNA) methylation. The objective of this study was to explore the effect of m 6A RNA methylation on atherosclerotic vulnerable plaque by FTO knockdown. Methods: A tota...

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Bibliographic Details
Published in:Revista brasileira de cirurgia cardiovascular 2023-02, Vol.38 (1), p.124-131
Main Authors: Qi, Chunmei, Li, Haoran, Yu, Yongshu, Hao, Ji, Zhang, Hao, Wang, Lele, Jin, Jingjing, Zhou, Qiang, Hu, Ya, Zhang, Chengmeng, Zhang, Qingdui
Format: Article
Language:Portuguese
Subjects:
CARDIAC & CARDIOVASCULAR SYSTEMS
SURGERY
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Summary:ABSTRACT Introduction: Knockdown of fat mass and obesity-associated gene (FTO) can induce N6-methyladenosine (m 6A) ribonucleic acid (RNA) methylation. The objective of this study was to explore the effect of m 6A RNA methylation on atherosclerotic vulnerable plaque by FTO knockdown. Methods: A total of 50 New Zealand white rabbits were randomly divided into pure high-fat group, sham operation group, vulnerable plaque group, empty load group, and FTO knockdown group (10 rabbits/group). Results: Flow cytometry showed that helper T (Th) cells in the FTO knockdown group accounted for a significantly higher proportion of lymphocytes than in the vulnerable plaque group and empty load group (P
ISSN:1678-9741
DOI:10.21470/1678-9741-2021-0039