A concise total synthesis of (R)-fluoxetine, a potent and selective serotonin reuptake inhibitor

(R)-Fluoxetine, potent and selective serotonin reuptake inhibitor, has been synthesized in six steps, 50% overall yield and 99% ee from benzaldehyde via catalytic asymmetric allylation with Maruoka's catalyst.

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Bibliographic Details
Published in:Journal of the Brazilian Chemical Society 2005-06, Vol.16 (3a), p.495-499
Main Authors: Fátima, Ângelo de, Lapis, Alexandre Augusto M., Pilli, Ronaldo A.
Format: Article
Language:English
Subjects:
CHEMISTRY, MULTIDISCIPLINARY
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Description
Summary:(R)-Fluoxetine, potent and selective serotonin reuptake inhibitor, has been synthesized in six steps, 50% overall yield and 99% ee from benzaldehyde via catalytic asymmetric allylation with Maruoka's catalyst.
ISSN:0103-5053
1678-4790
DOI:10.1590/S0103-50532005000300026