A concise total synthesis of (R)-fluoxetine, a potent and selective serotonin reuptake inhibitor

(R)-Fluoxetine, potent and selective serotonin reuptake inhibitor, has been synthesized in six steps, 50% overall yield and 99% ee from benzaldehyde via catalytic asymmetric allylation with Maruoka's catalyst.

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Published in:Journal of the Brazilian Chemical Society 2005-06, Vol.16 (3a), p.495-499
Main Authors: Fátima, Ângelo de, Lapis, Alexandre Augusto M., Pilli, Ronaldo A.
Format: Article
Language:English
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CHEMISTRY, MULTIDISCIPLINARY
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container_issue 3a
container_start_page 495
container_title Journal of the Brazilian Chemical Society
container_volume 16
creator Fátima, Ângelo de
Lapis, Alexandre Augusto M.
Pilli, Ronaldo A.
description (R)-Fluoxetine, potent and selective serotonin reuptake inhibitor, has been synthesized in six steps, 50% overall yield and 99% ee from benzaldehyde via catalytic asymmetric allylation with Maruoka's catalyst.
doi_str_mv 10.1590/S0103-50532005000300026
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subjects CHEMISTRY, MULTIDISCIPLINARY
title A concise total synthesis of (R)-fluoxetine, a potent and selective serotonin reuptake inhibitor
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